ICWS: Caphalosporins and ...many others!

Question 1

what is MOA of cephalosporins?

Answer 1

activate cell wall autolytic enzymes thru blocking of terminal cross-linking of peptidoglycan

Question 2

are cephalosporins similar to penicilins?

Answer 2

Yes. chemically ..both have beta-lactam ring structure.

Question 3

how is first gen. cephalosporins’ activity against G+ and G-?

Answer 3

good against G+ and moderate against G-

Question 4

is MSSA susceptible or resistant to First gen cephalosporins?

Answer 4

MSSA and most G+ are susceptible, however MRSA is resistant.

Question 5

can you use first gen. cephalosporins for penicillin allergic pts?

Answer 5

yes.

Question 6

can first gen. cephalosporins be given orally?

Answer 6

some are acid resistant like cephalexin

Question 7

are first gen. cephalosporins ß-lactamase resistance?

Answer 7

yes. increased ß-lactamase Resistance

Question 8

how are first gen. cephalosporins excreted?

Answer 8

renal

Question 9

what is the DOC of surgical prophylaxis?

Answer 9

Cefazolin (IV,IM)

Question 10

what are different groups of cephalosporins?

Answer 10

First generation( narrow spectrum), second generation (intermediate spectrum), third generation (broad spectrum), fourth generation, “unnamed” generation

Question 11

how is 2nd gen. cephalosporins activity against G+ and G-?

Answer 11

lower against G+ and somewhat increased against G-

Question 12

do 2nd gen. cephalosporins have antipseudomonal activity?

Answer 12

Nope.

Question 13

are 2nd gen. cephalosporins ß-lactamase Resistance?

Answer 13

yes. increased ß-lactamase Resistance

Question 14

how are 2nd. gen. cephalosporins excreted?

Answer 14

mostly renal

Question 15

what the prototype of 2nd gen. cephalosporins ?

Answer 15

cefaclor (oral)