ICP5: Biochemical Events in Dental Plaque Flashcards
Ultimately what causes caries?
Bacteria
How would you describe the structure of plaque?
Highly organised bacteria
What is the water and solid composition of dental plaque?
- 80% Water
- 20% Solid
20% of plaque composition is solid. What is this ‘solid’ made up from?
- 50% Bacterial and Salivary proteins
- 25% Carbohydrates and lipids
- 25% inorganic components
What are the carbohydrates and lipids in the dental plaque synthesised from?
Synthesised by the bacteria in the plaque
What is plaque fluid?
Extracellular aqueous phase of dental plaque
In nL how much plaque fluid can be found in a 500µg wet weight plaque sample?
150nL
What can changes in ionic composition of plaque fluid lead to?
Cariogenic conditions
What is rested plaque fluid?
Plaque fluid one to several hours after eating
What is starved plaque fluid?
Plaque fluid following overnight fasting
Which plaque fluid contains more amino acids? Rested or Starved?
Rested
Which plaque fluid is more acidic? Rested or Starved?
Rested
What is the main acid involved in caries formation?
Lactic Acid
What contributes to the extent of pH drop after glucose challenge? 5
- Type and amount of sugars available
- Bacteria Present
- Salivary composition and flow
- Other food ingested
- Thickness and age of dental plaque
What is the resting plaque pH of a caries-inactive patient?
Compare this to a patient that is caries-prone
Resting pH is roughly 6.5-7
Caries-prone has a Lower resting pH
