IC11 Flashcards
When is antidepressant indicated for MDD?
Moderate MDD
Antidepressants cannot be used alone in which condition?
Bipolar disorder, risk of mania switch from bipolar depression
1st line antidepressants
Mirtazapine, SSRI, SNRI, bupropion
Which medication is also indicated for diabetic neuropathy, fibromyalgia & chronic MSK pain?
Duloxetine (SNRI)
All serotonergic agents cause which side effects
GI, sexual dysfunction
Which medication may help to reverse GI / sexual dysfunction caused by SSRI/SNRI
Mirtazapine
Which medication is preferred in underweight / poor appetite
Mirtazapine
Which medication can cause/ worsen hypertension
Venlafaxine
Which medication is preferred in ppl with insomnia
Mirtazapine (cause sedation)
Which medication has no serotonergic effects?
Bupropion
Which medication has minimal sexual effects?
Bupropion (no serotonergic effects)
In which population is bupropion not suitable for?
Hx of seizure, eating disorder, psychosis
Drugs with minimal CYP intx
Mirtazapine, Escitalopram, Venlafaxine, Desvenlafaxine, Vortioxetine
Discontinuation symptoms least likely with____ (due to long T1⁄2) but most likely with ____ and____ (due to short T1⁄2)
Fluoxetine; Paroxetine and Venlafaxine
Strong inhibitors of 1A2
Fluvoxamine, Ciprofloxacin
1A2 substrates
Theophylline, Amiodarone, Warfarin-R, Agomelatine
2C19 substrate
Warfarin-R
Strong 2C19 inhibitors
Fluvoxamine, Omeprazole
2D6 inhibitors
Fluoxetine, Paroxetine, Bupropion
3A4 substrate
Simvastatin, Lovastatin
Nifedipine, Amlodipine, Diltiazem
3A4 inhibitor
Grapefruit juice
3A4 inducer
*Rifampicin
*Carbamazepine
*Phenytoin
*St. John’s Wort
