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PR3153 > IC11 > Flashcards

IC11 Flashcards

1
Q

When is antidepressant indicated for MDD?

A

Moderate MDD

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2
Q

Antidepressants cannot be used alone in which condition?

A

Bipolar disorder, risk of mania switch from bipolar depression

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3
Q

1st line antidepressants

A

Mirtazapine, SSRI, SNRI, bupropion

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4
Q

Which medication is also indicated for diabetic neuropathy, fibromyalgia & chronic MSK pain?

A

Duloxetine (SNRI)

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5
Q

All serotonergic agents cause which side effects

A

GI, sexual dysfunction

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6
Q

Which medication may help to reverse GI / sexual dysfunction caused by SSRI/SNRI

A

Mirtazapine

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7
Q

Which medication is preferred in underweight / poor appetite

A

Mirtazapine

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8
Q

Which medication can cause/ worsen hypertension

A

Venlafaxine

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9
Q

Which medication is preferred in ppl with insomnia

A

Mirtazapine (cause sedation)

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10
Q

Which medication has no serotonergic effects?

A

Bupropion

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11
Q

Which medication has minimal sexual effects?

A

Bupropion (no serotonergic effects)

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12
Q

In which population is bupropion not suitable for?

A

Hx of seizure, eating disorder, psychosis

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13
Q

Drugs with minimal CYP intx

A

Mirtazapine, Escitalopram, Venlafaxine, Desvenlafaxine, Vortioxetine

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14
Q

Discontinuation symptoms least likely with____ (due to long T1⁄2) but most likely with ____ and____ (due to short T1⁄2)

A

Fluoxetine; Paroxetine and Venlafaxine

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15
Q

Strong inhibitors of 1A2

A

Fluvoxamine, Ciprofloxacin

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16
Q

1A2 substrates

A

Theophylline, Amiodarone, Warfarin-R, Agomelatine

17
Q

2C19 substrate

A

Warfarin-R

18
Q

Strong 2C19 inhibitors

A

Fluvoxamine, Omeprazole

19
Q

2D6 inhibitors

A

Fluoxetine, Paroxetine, Bupropion

20
Q

3A4 substrate

A

Simvastatin, Lovastatin
Nifedipine, Amlodipine, Diltiazem

21
Q

3A4 inhibitor

A

Grapefruit juice

22
Q

3A4 inducer

A

*Rifampicin
*Carbamazepine
*Phenytoin
*St. John’s Wort

PR3153 (17 decks)

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