IC 9 - Pharm Tech (1) Flashcards
What are the 4 advantages of intranasal delivery?
- Non-invasive
- Can self administered
- Bypass hepatic first pass
- Short onset of effect
What are the 7 barriers to CNS drug delivery system?
- Nasal epithelial layer
- Nasal Muscus (5µm)
- Metabolic enzymes
- Efflux pumps
- Hair
- Mucociliary clearance
- Volume
What are the characteristic of ideal drug candidates?
- ≤5 H Bond donors
- ≤10 H Bond acceptor
- < 500 Da
- Log P < 5
- Unionised
For nasal to brain access, hydrophilic drugs should be _____ 300Da
less than
For nasal to brain access, lipophilic drugs should be _____ 1KDa.
less than
List at least 3 advantages of having a delivery system.
- Make drug physically manageable
- Improve solubility
- Improve absorption
Others: Protect drug candidate from degradation and excretion, improve drug retention, reduce side effects through targeting, increase dosing, reduce frequency of administration
What are the common excipients of nasal spray?
Diluent, buffer salts, preservatives, stabilizer, permeation enhancers, viscosity modifiers
What are the three considerations when formulating nasal spray?
- pH (4-7.4)
- Tonicity (300-700 mOsm)
- Volume (max 200µL)
What are the considerations for container vessel material to hold formulation of nasal spray?
- No interactions with drugs and excipients
- Protect from contamination and degradation
What are the requirements of delivery device for nasal spray?
- Stability with formulated product
- User-friendly
- Reliability in use
What are the considerations when designing nasal spray device?
- Droplet size distribution
- Viscosity
- Spray pattern
- Plume geometry
- Dose volume
- Velocity
What are in-situ gels?
Low viscosity solutions initially but increase in viscosity once administered
What is an advantage of in situ gels?
Longer retention time
Low viscosity of in situ gels are exhibited at pH of _____.
4
