IBS

Question 1

Is IBS common?

Answer 1

Yes

Question 2

What kind of disorder is IBS

Answer 2

It is a sensory and motility disorder of the bowel

Question 3

Et. of IBS

Answer 3

Unclear

Proposed links: lactose, stress, smoking, diet

Question 4

Patho of IBS

Answer 4

Malabsorption of polyols and fermented CHO
Normal flora process this and as a by product make gas -> flatulence
This disrupts the fx of the GI tract
Molecular signalling defect in serotonin
IBS Mnfts and fx problems occur

Question 5

What is the function of serotonin

Answer 5

It is involved with secretion, perfusion, motility and pain reflex)

Question 6

What cells secrete serotonin

Answer 6

Enterochromaffin cells

Question 7

Mnfts of IBS

Answer 7

Varied severity 
Flatulence 
Alt. diarrhea, constipation 
Abdm pain and discomfort 
Mucoid stools

Question 8

Dx of IBS

Answer 8

Exclude organic disease

Various scopes (endoscopy, colonoscopy, sigmoidoscopy)

Presentation

Question 9

Tx of IBS

Answer 9

Avoid offending foods
Decrease stress
PRN Meds: antidiarrheals, antispasmodics, laxatives and SOMETIMES abx

Question 10

Why do we caution with use of Abx?

Answer 10

It wipes out normal flora so that Mnfts of IBS will decrease but if too much abx are used, then we have a total loss of normal flora and the risk of infection rises a lot