IBD Flashcards
crohns disease history
may be present unrecognised for years. recurring periods of flare-ups and remission
UC history
gradula onset of diarrhoea with blood and mucus +/- weight loss and blood on rectal examination
crohns symptoms
abdominal pain +/- diarrhoea
bloody bowel movements
intermittent flatulence and bloating
intestinal stenosis: vomiting and nausea
UC symptoms
variable pain: from mild discomfort to painful bowel movements or painful cramping with bowel movements
site of crohns
terminal ileum but may involve colon, stomach, or even mouth
site of UC
continuous from rectum up to colon
what are the extra intestinal symptoms found in both CD and UC
joints - seronegative spondylarthropathy
mouth - aphthous ulcers
skin - pyoderma gangrenous (non-healing tissue necrosis)
eyes: inflammation (middle and inner parts - uveitis, outer connective tissue - episcleritis)
blood: anaemia
what ethnicity has a higher prevalence of IBD
the west in comparison to Asia
what does monozygotic twins mean
genetically identical
what does dizygotic twins mean
non-identical
share 25% of genes
In what condition is genetic influence stronger
CD stronger than UC
5-ASA mode of action
acts from gut-lumen
rapidly inactivated after resoption (=> direct action on cells outside gut unlikely)
shown to affect gut bacteria
how does the immune system identify those bugs in the gut that actually play a role in IBD inflammation
bacteria that are coated by the patients secreted IgA and see if these bacteria can cause inflammation
bugs that ARE coated in IgA
IgA+
bugs that ARENT coated in IgA
IgA-
