IBD Flashcards
what are the 2 major forms of IBD?
- ulcerative colitis
- Chron’s disease
whata re the risk factors of IBD?
- genetic predisposition
- environmental factors (smoking, diet, obesity, gut microbiome)
- obesity (only for CD)
what is the pathogenesis of IBD?
- defective interactions b/ mucosal immune system and gut flora
- leads to disrupted innate immunity
- physical damage
what immune cytokines are involved in UC?
- Th2 mediated
- dependant on IL-5 and IL-13 cytokines
what does UC affect?
- mucosa and submucosa
- starts in rectum, spreads proximally
- always continuous
- surgery can be curative
what cytokines are involved in Chron’s?
- Th1 mediated (worst inflammatory response)
- dependant on TNF-alpha
what does Chron’s affect?
- penetrates all of gut wall
- affects any point of GIT
- causes patchy inflammation
- abscesses, fissures and fistula
what are the clinical features of IBD?
- R iliac fossa pain
- skin rash
- diarrhoea, blood, mucus
- weight loss
- arthritis, athralgia
- abdo pain
- anaemia
what are the supportive therapies for IBD?
- fluid/ electrolyte replacement
- blood transfusion
- nutritional support
what are the classic symptomatic treatments?
- glucocorticoids e.g. prednisolone
- aminosalicylates e.g. mesalazine
- immunosuppressives e.g. azathioprine
what are the potentially curative treatments?
- manipulation of microbiome
- anti-TNF alpha
- anti-alpha-4-integrins
give 2 aminosalicylates and what are they?
mesalazine
olsalazine
anti-inflammatory drugs
are aminosalicylates used in UC and CD treatment?
- UC: 1st line in inducing and maintaining remission
- CD: not effective in active disease
what is the MoA of aminosalicylates?
- inhibition of IL-1, TNF-alpha, PAF
- dec. antibody secretion
- non-specific cytokine inhibition
- reduce cell migration
- localized inhibition of immune responses
describe the metabolism of mesalazine?
- does not need to be metabolised
- absorbed by small bowel and colon