anti-convulsants Flashcards

1
Q

define seizure

A

sudden changes in behaviour caused by electrical hypersynchronisation of neuronal networks in cerebral cortex

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2
Q

how can brain activity be measured?

A
  • EEG

- MRI

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3
Q

what are general seizures and the types?

A
  • begins simultaneously in both hemispheres of brain
    1. tonic clonic: loss of consciousness
    2. absence: brief staring episodes with behavioural arrest
    3. tonic: sudden muscle stiffening/ sudden loss of muscle control
    4. myoclonic: sudden, brief muscle contractions
    5. status epilepticus: > 5 min of continuous seizure activity
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4
Q

describe what happens in tonic-clonic seizures

A
  • loss of consciousness
  • muscle stiffening
  • jerking/ twitching
  • deep sleep
  • wakes up
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5
Q

what are partial/ focal seizues and what are the types?

A
  • begins within particular area, may spread out
  • simple: retained awareness/ consciousness
  • complex: impaired awareness/ consciousness
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6
Q

describe the steps to neurotransmission at glutamatergic synpase

A
  1. VGSC opens –> membrane depolarisation
  2. VGKC opens –> membrane repolarisation
  3. Ca influx through VGCCs –> vesicle exocytosis
  4. synaptic vesicle associated protein (SV2A) allows vesicle attachment to presynaptic membrane
  5. glutamate activated excitatory post-synaptic receptors (e.g. NMDA, AMPA)
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7
Q

name 2 VGSC blockers

A
  • Carbamazepine

- Lamotrigine

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8
Q

what does Carbamazepine do?

A
  • stabilizes inactive state of Na channel

- reduces neuronal activity

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9
Q

what does Lamotrigine do?

A
  • inactivates Na channels

- reduces glutamate neuronal activity

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10
Q

what are the pharmacokinetics of carbamazepine?

A
  • enzyme inducer
  • onset of activity within 1 hour
  • 16-30 hour half life
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11
Q

what are the indications for use of carbamazepine?

A
  • tonic-clonic

- partial

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12
Q

what are the pharmacokinetics of lamotrigine?

A
  • onset of activity within 1 hour

- 24-34 hour half life

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13
Q

what are the indications for use of lamotrigine?

A
  • tonic clonic

- absence

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14
Q

name a VGCC blocker and how it works

A
  • Ethosuzimide
  • T-type Ca channel antagonist
  • reduces activity in relay thalamic neurones
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15
Q

what is the pharmacokinetics and indications of ethosuximide?

A
  • long half life = 50 hours

- used in absence seizures

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16
Q

what is levetiracetam and when is it indicated?

A
  • binds to synaptic vesicle associated protein
  • prevents glutamate release
  • used in myoclonic seizures
17
Q

what is topiramate and when is it indicated?

A
  • inhibits NDMA and kainite receptors
  • also affects VGSCs and GABA receptors
  • used in myoclonic seizures
18
Q

describe what happens in GABAergic synapses?

A
  • GABA can be released tonically and following neuronal stimulation
  • GABA activated inhibitory post-synaptic GABAa receptors
  • these receptors are Cl channels = membrane hyperpolarisation
  • GABA taken up by GAT and metabolised by GABA-T
19
Q

describe diazepam and when is it indicated

A
  • GABA receptor, PAM –> inc. GABA-mediated inhibition
  • rectal gel = fast onset
  • indicated for status epilepticus
20
Q

what is the MoA of sodium valproate and indications for use?

A
  • inhibits GABA-T
  • inc. GABA mediated inhibition
  • fast onset = 12 hour half life
  • indicated for all forms of epilepsy