Ibd Flashcards
Definition of IBD
“A chronic idiopathic intestinal inflammation including Ulcerative Colitis
Common risk factors for IBD
“Geographical factors
Ulcerative Colitis (UC) pattern of inflammation
“Diffuse
Most common site involvement in UC
“Rectum and recto-sigmoid (40-50%).”
Pancolitis percentage in UC
“Occurs in 20% of cases.”
Genetic factor difference between UC and Crohn’s
“No specific gene in UC
Smoking and UC
“Smokers are less likely to develop UC
Appendectomy and UC risk
“Appendectomy at a young age reduces the likelihood of developing UC.”
Common symptoms of UC
“Bloody diarrhea
Common complications of UC
“Severe bleeding (1%)
Key serologic markers in UC
“p-ANCA (50-80% of cases) and ASCA (less sensitivity in indeterminate colitis).”
Endoscopic findings in mild UC
“Redness
Endoscopic findings in moderate UC
“Granularity
Endoscopic findings in severe UC
“Severe ulcerations with spontaneous bleeding.”
Imaging findings in UC
“Colonic dilation in toxic megacolon
Indications for surgery in UC
“Severe hemorrhage
Characteristic feature of Crohn’s disease
“Transmural inflammation with skip lesions.”
Most common site of Crohn’s disease
“Terminal ileum and cecum (40-50%).”
Rectal involvement in Crohn’s disease
“Typically spared.”
Endoscopic findings in Crohn’s disease
“Cobblestone appearance
Characteristic histological finding in Crohn’s disease
“Non-caseating granulomas (found in 60% of surgical specimens).”
Common clinical presentation of Crohn’s disease
“Colicky RLQ pain
Extra-intestinal manifestations of Crohn’s
“Arthropathy
Nutritional deficiencies in Crohn’s disease
“Vitamin B12 deficiency
Common complications of Crohn’s disease
“Fistulas
Gold standard for Crohn’s disease diagnosis
“Colonoscopy with biopsy.”
Characteristic imaging findings in Crohn’s disease
“Skip lesions
Role of fecal calprotectin in IBD
“Useful non-invasive marker to distinguish IBD from IBS.”
Mainstay treatment for mild IBD
“5-Aminosalicylic acid (5-ASA) like sulfasalazine or mesalamine.”
Role of corticosteroids in IBD treatment
“Used for moderate to severe disease
Immunosuppressants used in IBD
“Azathioprine
Biologic therapy for IBD
“TNF-alpha inhibitors like Infliximab.”
Antibiotics used in Crohn’s disease
“Ciprofloxacin and Metronidazole.”
Surgical indications in Crohn’s disease
“Severe complications like strictures
Main difference between Crohn’s and UC in terms of surgical management
“Surgery is curative in UC but not in Crohn’s disease.”
Which IBD subtype is more associated with fistulas?
“Crohn’s disease.”
Which IBD subtype has a higher risk of colorectal cancer?
“Ulcerative colitis.”
IBD treatment approach for perianal Crohn’s disease
“Combination of biologics
Which IBD subtype is more likely to present with toxic megacolon?
“Ulcerative colitis.”
Role of enteral nutrition in Crohn’s disease
“Can be effective in inducing remission
Main diagnostic tool for differentiating UC and Crohn’s
“Colonoscopy with biopsy.”
Common surgery for UC
“Total proctocolectomy with ileal pouch-anal anastomosis (IPAA).”
Which IBD subtype has a continuous pattern of inflammation?
“Ulcerative colitis.”
What are crypt abscesses associated with?
“Ulcerative colitis.”
Characteristic endoscopic feature of Crohn’s disease
“Cobblestone mucosa with deep ulcerations.”
First-line therapy for mild to moderate Crohn’s disease
“Oral 5-ASA (Mesalamine or Sulfasalazine).”
Most common site of extra-intestinal manifestations in IBD
“Joints (Reactive arthropathy).”
Recommended colonoscopy frequency for patients with long-standing UC
“Every 1-2 years.”
Role of fecal lactoferrin in IBD
“Biomarker for intestinal inflammation
Management of fulminant UC
“IV steroids
