IBD

Question 1

What are the subtypes of IBD?

Answer 1

Ulcerative Cholitis

Crohn’s Disease

Question 2

What is inflammatory Bowel Dz?

What is it characterized by?

Answer 2

Inflammatory changes in the GI tract, caused by an immune response against gut bacteria.
Characterized by lifelong exacerbations

Question 3

What is Ulcerative Colitis?

Answer 3

UC is characterized by diffuse mucosal inflammation in a continuous pattern limited to the colon. It usually begins in the rectosigmoid area and proceeds proximally, but it may develop in extensive areas of the colon at the same time

Question 4

What is Crohn’s Dz

Answer 4

CD is characterized by transmural inflammation in a discontinuous pattern that can occur in any part of the GI tract from mouth to anus. The distal ileum and colon are the most common sites of CD involvement

Question 5

What is the age of onset for IBD?

Answer 5

Bi-modal
More common in 15-30
Second peak is in 60’s

Question 6

What medications are used for CD?

Answer 6

Steroids for acute flares
Sulfasalazine, Mesalamine- best w/CD
Immunomodulators: 6-MP/Imuran, Methotrexate
Anti-TNF
Abx
Surgery will not cure

Question 7

What medications are used for UC?

Answer 7

Mesalamine- maintenance
Steroids (prednisone)- for acute flares, steroid dependance is common though
Cyclosporine- for steroid refractory pts
6-MP/Imuran- secere, refractory dz
Anti-TNF for steroid intolerany
Surgery is an option for cure

Question 8

How are these adz diagnosed and how do they differ?

Answer 8

Diagnosis involves clinical, endoscopic, and histologic criteria

Question 9

What are the extraintestinal features of uncontrolled dz?

Answer 9

Ocular disorders
Apthous stomatitis
Ankylosing spondylitis
Primary sclerosing cholangitis/hepatobiliary disorders
Nephrolithiasis
Sacroileaitis
Thromboembolic complications
Peripheral arthritis
Skin disorders