Acute, Autoimmune, and Chronic Hepatitis Flashcards
What are the principal functions of the liver?
Metabolic: Detoxification/breakdown of toxins, hormones and drugs, synthesis of bile, albumin, clotting factors, gluconeogenesis, cholesterol/TG production
Storage: glycogen, Vitamin A/D/B12, iron, copper
What are the labs used to evaluate the synthestic function of the liverand presence of inflammation (hepatocellular and cholestatic injury)?
Synthetic fxn: Albumin and PT (factors II, VII, IX,X)
Inflammation of liver: ALT/AST/Gamma GGT
Biliary obstruction: Alkaline phosphatase (CBT)
What are the various causes of acute hepatitis?
Viral (A,B,C,D) Drugs Toxins Vascular Autoimmune Metabolic disorders
Causes of chronic hepatitis?
Viral B and C Drugs Alcohol NAFLD Autoimmune Metabolic Disorders
What are the basic dz’s associated with autoimmune/hereditary hepatitis?
Wilson’s dz
Hemochromatosis
Alpha1 antitrypsin deficiency
What labs and imaging studies can be used to diagnose hepatocellular cancer?
Tumor markers: AFP>400 (alpha fetoprotein)
CT scan, Ultrasound, MRI
PE= friction rubs
What labs and imaging studies can be used to diagnose cholestatic patterns?
Bilirubinase,
ALP
5-nucleotidase
Gamma GGT
What are the basic metabolic causes of hepatitis?
Alcoholic liver dz
Non-alcoholic fatty liver dz (obesity)
What are the routes of infection for the viral hepatitis?
A- Feces B-Blood/Blood, Boody fluids C- Blood/blood D- Blood/blood, body fluids E- Feces
What serum markers are present when someone has been infected with Hepatitis B?
HBVcAb (contracted)
HBVsAg (chronic)
HBVsAb (free of virus)
What serum markers are present when someone has been immunized from Hepatitis B?
HBVsAb
What serum markers are present when someone has an active replicating virus?
HBVeAb
HBVeAg (actively replicating)
