i think lec 7 Flashcards
differences in voltage-gated ion channel isoforms contribute to differences in….
action potential waveform and firing patterns
different spike after-potentials
seen in different cell types
contribute to differences in firing patterns
firing patterns are modulated by
membrane potential developmental stage disease (channelopathies) pharmacological agents synaptic activity intrinsic activity
intrinsic properties of neurons
to do with channels
recovery from activation requires
time
negative membrane potential
why are APs narrower in OLM cells
the membranes spend less time at depolarised potentials
importance of APs in OLM cells having a large AHP
push the membranes to more hyperpolarised potentials
why can interneurons fire more frequenctly
they can recover more quickly
3 states of voltage gated activation channels
resting
activated
inactivated
states of voltage gated channels depend on
membrane potential
resting state
channels are closed but have ability to open
negative/resting membrane potential
activated state
channels are open
occurs during depolarisation
inward current seen in voltage clamp recording
inactivated channel state
channels are locked closed
recovering from activation
how do you calculate the V half activation using a voltage clamp graph
plot the size of current against the test potential
what forms the pores for sodium channels
alpha subunits
