i think lec 7

Question 1

differences in voltage-gated ion channel isoforms contribute to differences in….

Answer 1

action potential waveform and firing patterns

Question 2

different spike after-potentials

Answer 2

seen in different cell types

contribute to differences in firing patterns

Question 3

firing patterns are modulated by

Answer 3

membrane potential
developmental stage
disease (channelopathies)
pharmacological agents
synaptic activity
intrinsic activity

Question 4

intrinsic properties of neurons

Answer 4

to do with channels

Question 5

recovery from activation requires

Answer 5

time

negative membrane potential

Question 6

why are APs narrower in OLM cells

Answer 6

the membranes spend less time at depolarised potentials

Question 7

importance of APs in OLM cells having a large AHP

Answer 7

push the membranes to more hyperpolarised potentials

Question 8

why can interneurons fire more frequenctly

Answer 8

they can recover more quickly

Question 9

3 states of voltage gated activation channels

Answer 9

resting
activated
inactivated

Question 10

states of voltage gated channels depend on

Answer 10

membrane potential

Question 11

resting state

Answer 11

channels are closed but have ability to open

negative/resting membrane potential

Question 12

activated state

Answer 12

channels are open
occurs during depolarisation
inward current seen in voltage clamp recording

Question 13

inactivated channel state

Answer 13

channels are locked closed

recovering from activation

Question 14

how do you calculate the V half activation using a voltage clamp graph

Answer 14

plot the size of current against the test potential

Question 15

what forms the pores for sodium channels

Answer 15

alpha subunits

Question 16

sodium channel beta subunits

Answer 16

expressed to form covalent bonds and alter properties of channel

Question 17

AP properties of OLM IN

Answer 17

slower rate of rise of the AP
lower peak of the AP
more depolarised AP threshold
larger AHP

Question 18

AHP

Answer 18

after-hyperpolarisation

Question 19

action potential definition

Answer 19

short lasting event where the electrical membrane potential of a cell rapidly rises and falls

Question 20

examples of cells where APs occur

Answer 20

neurons
muscle cells
cardiac cells
endocrine cells

Question 21

APs require a cell to have a

Answer 21

negative resting membrane potential

Question 22

neuron examples from the hippocampus

Answer 22

CA1 pyramidal neuron

O-LM interneuron

Question 23

CA1 pyramidal neuron

Answer 23

glutamatergic

Question 24

O-LM interneuron

Answer 24

GABAergic