Hyppthalamic Hormones Flashcards
Paraventriculer nucleus site
Within th BBb or outside
Adjacent of the 3rd ventricle
Within the BbB
Paraventriculer nucleus have to types of neurons
Magnocelluler ADH and oxytocin
Parvocelluler ADH TRH CRh
Paraventriculer nucleus hormones
CRH
TRH
Arcuate nucleus
Dopamine and GHRH
Preoptic nucleus
GRH
Periventrinculer nucleus
Somatostatins
Supraoptic and Paraventriculer
ADh and oxytocin ‘
ADh supraoptic parvo and mango
Oxytocin Paraventriculer parvocelluer ,
Define dopamine
Prolactin inhibiting hormone
How many receptors does dopamine have
5 receptors
Dopamine is produced in 3 sites
Substantia nigra
Arcuate nucleus
Medulla of the adrenal glands
Mention 5 functions for dopamine
1 ) have a role in behavior , cognition , voluntary movements
2) inhibits prolactin
3 inotropic
4 chronotropic ‘5bstimulate comiiting via chemoreceptors trigger zone
What’s metoclopromide
Is dopaminergic receptor antagonist
Can dopamine cross the BBB
It’s can’t cross the BBB .
Dopamine is metablized by
COMT
mAo
GNrH is secreted by which nucleus
Preoptic nucleus
GNrH secretion pattern
Pulsation manner
When is GNrH secretion pattern is pulstile frequency high and when is low
High in the follicular phase
Low in the late luteal phase
Half life of GNrH
2-4 mins
GNrH gene present on which chromosome
On chromosome 8
Relation between GNrH , insulin and prolactin
Insulin increases GNrH activity
Prolactin decreases GNrH activity .
Activity of the GNrH in th childhood
Is low
Describe somatostatin اكتر اشي بميزه
Somatostatin is GHRH inhibitor
And inhibit TSH as well .
Somatostain is secreted by
Intestine
Stomach
Pancreatic cells D cells
Thyroid cell parafolliculer cell s
Periventriculer cells
What does somatostatin inhibits
1 GH
2 tsh
3 gastric emptying intestinal motility
Suppresses release of pancreatic hormone
Inhibits
Gastrin
Cck
Motility
Secretin
Insulin
Glucagon
VIP vasoactive intestinal peptide .
TRH released from
And stimulate release of
From the Paraventriculer nucleus
Secret the release of TSH , prolactin
Melatonin is derived from
Serotonin
Describe the activity of melatonin
Bio rhythmic and diurnal
What increase release of the melatonin
Darkness
Hypoglycemia
Sites of melatonin production
👁️ retina , lens of the eye 👁️ , GIT , pineal gland , suprachiasmatic nucleus .
Gonadotrophins and melatonin relation
Melatonin inhibits gonadotrophins .