Hypoxia And Cyanosis Flashcards
Hypoxia induced increase in expression of key proteins is governed by
HIF1
Atp production inadequate to mert energy reqts, cell membrane depolarization leads to uncontrolled ca influx… Leading to
Cell swelling and cell death
Causes impaired judgment, motor incoordination and clinical picture resembling acute acohol intox
Acute hypoxia
Characterized by headache secondary to cerebral vasodilation…
High altitude illness
Manifested by severe headache and papilledema and coma
HIgh altitude cerebal edema
Cyanosis present since birth or infancy
Congenital heart disease
How to differentiate central from peripheral cyanosis?
Gentle warming of cyanotic extrrmity abolish peripheral not central
Peripheral cyanosis is not associated with?
Clubbing
Clubbing with respiratory diseases is associated with
Hypertrophic osteoarthripathy
Florid skin characteristic
Polycythemia vera
Cherry colored flush
CO Hb
Detectable Fall of o2 sat in dark skinned
75%
Cyanosis becomes apparent when concentration of reduced hemoglobin in capillary exceeds..
4 g/dl
Cyanosis in altitude ascent of
4000m 13000ft
Secondary polycythemia is present and clubbing
Chronic central cyanosis