Hypoxia And Cyanosis Flashcards
Hypoxia induced increase in expression of key proteins is governed by
HIF1
Atp production inadequate to mert energy reqts, cell membrane depolarization leads to uncontrolled ca influx… Leading to
Cell swelling and cell death
Causes impaired judgment, motor incoordination and clinical picture resembling acute acohol intox
Acute hypoxia
Characterized by headache secondary to cerebral vasodilation…
High altitude illness
Manifested by severe headache and papilledema and coma
HIgh altitude cerebal edema
Cyanosis present since birth or infancy
Congenital heart disease
How to differentiate central from peripheral cyanosis?
Gentle warming of cyanotic extrrmity abolish peripheral not central
Peripheral cyanosis is not associated with?
Clubbing
Clubbing with respiratory diseases is associated with
Hypertrophic osteoarthripathy
Florid skin characteristic
Polycythemia vera
Cherry colored flush
CO Hb
Detectable Fall of o2 sat in dark skinned
75%
Cyanosis becomes apparent when concentration of reduced hemoglobin in capillary exceeds..
4 g/dl
Cyanosis in altitude ascent of
4000m 13000ft
Secondary polycythemia is present and clubbing
Chronic central cyanosis
Digital clubbing not present in these rare conditions
Met HB and Sulf HB
Most common cause of respiratory hupoxia
V/q mismatch
Condition wherein intrapulmonleft to right shunting is the mechanism
Atelectasis
In CO poisoning dissociation curve is shifted to
Left
pao2 is normal but tissue and venous po2 are reduced as a conqequence of reduced tissue perfusion and greater tissue oxygen extraction
Circulatory hypoxia
Conditions for circ hypoxia
Shock
Heart failurr
Tissues are unable to utilize oxygen and results to venous blood having high oxygen tension
Histotoxic hypoxia
Important mechanism for chronic hypoxia
Increase in hb concentration and #rbcs
Define by ft:
High altitude illness
Chronic mountain sickness
13000 ft
Gt 13000 ft
