Hypothyroidism in children

Question 1

Most common cause

Answer 1

autoimmune thyroiditis

Question 2

Other causes
- post total-body […] - post […] treatment
- […] deficiency

Answer 2

irradiation, ALL
iodine

Question 3

Head and neck features
- Macroglossia
- Puffy face
- Loss of lateral […] of the eyebrow
- […] (depending on cause)​

Answer 3

third
Goitre

Question 4

Peripheral features
- […], thick skin
- […] hair
- […] secondary sexual hair​

Answer 4

Dry
Brittle
Scanty

Question 5

Cardiac features
- […]
- Cardiomegaly

Answer 5

Bradycardia

Question 6

Neurological features
- […] […] syndrome
- […] reflexes
- Cerebellar […]
- Peripheral […]

Answer 6

Carpal tunnel
Slow
ataxia
neuropathy

Question 7

Autoimmune causes
1. Hashimoto’s thyroiditis
- Anti-[…] ([…]) 90-95% of patients
- Anti-[…] 35-60% of patients
- Anti-TSH receptor (blocking): 10% of patients

2. […] thyroiditis
3. Autoimmune polyendocrine syndromes​

Answer 7

TPO, thyroperoxidase
thyroglobulin

Atrophic

Question 8

Congenital causes
- Thyroid […]
- […] syndrome (defect in […] synthesis)​

Answer 8

aplasia
Pendred, thyroxine

Question 9

Iodine deficiency/Excess Related Causes
- Infiltrative
- Sarcoid
- […]

Answer 9

Haemochromatosis