Hypopituitarism

Question 1

what is hypopituitarism?

Answer 1

inadequate production of one or more pituitary gland hormones

Question 2

What are the major causes of hypopituitarism

Answer 2

1. Pituitary macroadenoma - compress and cause dysfunction
2. Pituitary gland damage
   - Sheehan’s syndrome
   - Brain injury

Question 3

What is ‘Sheehan’s syndrome’

Answer 3

1. post partum haemorrhage causing post partum necrosis of the pituitary gland

Question 4

Clinical presentation - GH deficiency

Answer 4

short stature during childhood

Question 5

Clinical presentation - prolactin deficiency

Answer 5

lactation failure following delivery

Question 6

Clinical presentation - FSH/LH

Answer 6

females - primary/secondary amenorrhea

males - loss of libido, testicular atrophy, delayed puberty

Question 7

Clinical presentation - TSH deficiency

Answer 7

1. weight gain
2. cold intolerance
3. constipation
4. dry skin

Question 8

Clinical presentation - ACTH deficiency

Answer 8

1. weight loss
2. hypotension
3. hyponatraemia
4. hypoglycaemia

Question 9

Clinical presentation - central diabetes insipidus

Answer 9

1. polyuria

2. polydipsia

Question 10

Clinical presenation - mass effect

Answer 10

1. headache
2. visual field defect - bitemporal hemianopia
3. diplopia