hypolipémiant inhibiteurs PCSK9 Flashcards

1
Q

mécanisme inhib PCSK9

A

classe très récente, prescription hospit
mol dans plasma, fixe R LDL = Ac monoclonaux pour éviter endocytose

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2
Q

PDYN inhibe PCSK9

A

augmente nombre R LDL = diminue LDL (60%)
faible diminution VLDL et IDL

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3
Q

Médoc inhib PCSK9

A

alirocumab
evolocumab

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4
Q

alirocumab

A

praluent

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5
Q

evolocumab

A

repatha

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6
Q

PKIN inhib PCSK9

A

absorption : inj SC -> biodisponibilité 70 à 85%
T1/2 = 15j

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7
Q

indications inhib PCSK9

A

hyperC primaire (pure)
dyslipidémies mixtes

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8
Q

effets indésirables inhib PCSK9

A

réaction inf au point d’inj
état pseudo-grippal

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9
Q

contre-indication inhib PCSK9

A

hypersensibilité

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10
Q

interaction inhib PCSK9

A

statines ou hypolipémiant = augmente R LDL = augmente PCSK9

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