hypolipémiant inhib absorption intestinale stérols Flashcards

1
Q

mécanisme inhib abs stérols

A

inhib transporteurs stérols NPC1L1
diminue absorption intestinale C et phytostérols
inhib réabsorption C excrété dans bile

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2
Q

PDYN inhib abs stérols

A

diminue LDL (18%)
augmentation faible HDL

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3
Q

médoc inhib abs stérols

A

ezetimibe

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4
Q

ezetimibe

A

ezetrol

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5
Q

PKIN inhib abs stérols

A

absorption : rapide voie orale

métabolisme : dans intestin -> dérivés glucurono-conjugué actif
cycle entéro-hépatique
T1/2 =22h

elimination : 80% fèces

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6
Q

indication inhib abs stérols

A

hyperC pure IIa, synergie avec statines

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7
Q

effets indésirables inhib abs stérols

A

rares : atteinte hépatique réversible

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8
Q

interactions inhib abs stérols

A

fibrates = augmente concentration plasma ezetimibe
colestyramine et resine = diminue concentration plasma ezetimibe

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