Hypoadrenocorticism (Addison's Disease) Flashcards
What causes Primary Hypoadrenocorticism
(Addison’s Disease)?
Atrophy of the Adrenal Cortex resulting in decreased production of:
-Glucocorticoids
-Mineralocorticoids
What causes Secondary Hypoadrenocorticism
(Addison’s Disease)?
Lack of Adrenocorticotropic Hormone
(ACTH)
Less Common
Other causes of Hypoadrenocorticism (Addison’s Disease) - 4
- Trauma
- Fungal Infection
- Neoplasm (Neoplasia)
- Heriditary tendencies
Clinical Signs of Hypoadrenocorticism?
-Depression, Lethargy & Weakness
-Anorexia & Weight Loss
-V/D
-PU/PD
Symptoms frequently wax and wane over time
Diagnosis:
Which serum chemistry values are INCREASED as a result of Addison’s Disease?
Increased:
BUN
Creatinine
Ca (Calcium)
K (Potassium)
Diagnosis:
Which serum chemistry values are DECREASED as a result of Addison’s Disease?
Decreased:
Glucose
Albumin
Na (Sodium)
Diagnosis:
Which electrolyte ratio is low as result of Addison’s Disease?
Low Na:K ratio (sodium/potassium)
Which test can give a definitive diagnosis of Hypoadrenocorticism?
Adrenocorticotropic Hormone Stimulation Test (ACTH stim)
Describe the results of the Adrenocorticotropic Hormone Stimulation Test (ACTH stim) that would mean a definitive (positive) diagnosis of Addison’s Disease.
Low resting cortisol [ ], which would remain unchanged after administration of ACTH
Acute Crisis Management Treatment for Addison’s Disease
-Fluid Replacement (Normal Saline)
-Drug Therapy: replace & balance steroid
levels
Chronic Management for Addison’s Disease
-Daily oral steroid replacement
-DOCP injection every 25-30 days
-Monitor for signs of crisis
-Periodic Bloodwork: electrolytes
BUN & creatinine
The adrenal cortex produces both Glucocorticoids and Mineralocorticoids. These are what type of hormones?
Steroid Hormones
