Hypo-pit drugs Flashcards
Sermorelin MOA
synthetic GHRH
Somatotropin/ Somatrem MOA
Synnthetic GH
Sermorelin/ somatoropin/ somatrem indications
growth failure, praider willi, turners, short bowel syndrome
sermorelin/ somatrotropin/ somatrem contraindications
peds pts with closed plates, intracranial lesions, malignancy, diabetic retinopathy
sermorelin, somatorpin/ somatrem AE
leukemia, hypothyroid, insulin resistance, arthralgia, inc cyp 450
Mecasermin MOA
recombinant IGF-1
Mecasermin indications
laron dwarfism- mutations in GH receptor
Octeotide/ Lanreotide MOA
somatostatin analogue, inhibits GH
Octeotride/ lanreotide ind
pit adenoma, carcinoid crisis, VIP-oma, GI bleed (stops acid production)
Octeotride/ Lanreotide AE
GI: nausea/ comiting/ cramps
cardio: sinus brady cardia, conduction problems
gallstones
Pegvisomant MOA
GH receptor antagonist
Pegvisomant indications
refractive acromegaly
pegvisomant AE
increased adenoma size, inc aminotrnasferase
Gonadotrophs MOA and names
MOA: replace FSH and LH
Menotorpin (menopausal women), hCG, urofollitropin, follitropin
Gonadotophs indications
start ovulation for women with: hypo hypogonadism, PCOS.
male infertility for hypog/ hypog