Estrogens lecture Flashcards
Ethinyl Estradiol
syntetic steroidal estrogen (increases HDL, clotting factors and dec bone resproption) used for OC, vag atrophy, acne, delayed puberty….don’t use in cancer patients, pregnant, or DVTs
DES- (diethylstilbestrol
syntetic non-steroidal estrogen (increases HDL, clotting factors and dec bone resproption) used for OC, vag atrophy, acne, delayed puberty….don’t use in cancer patients, pregnant, or DVTs
other steroidal estrogens
Mestranol, quinestrol
other non-steroidal estrogens
chlorotrianisene, methallenestril
Tamoxifen
ERant in breast (part agonist in bone and endometrium)..used for breast cancer…don’t use in DVT/ pregnancy
Clomiphene
ERant in hypo and pituitary (partial ovarian agonist)…used for infertility from ovulatory disorder…don’t use in pregnancy DVT, cancer ect
Raloxifene
ER agonist in bone, antagonist at uterus/ breast….used for osteoporosis (don’t use in preg/ DVT
Fulvestrant
full ER antagonist…for metastatic BRCA cancer… don’t use in pregnancy
Anastrozole/Letrozole
araomatase reversible comp anatagonist…used for ER pos and metastatic cancer…lots of AE…more effective than serms but high risk of fractures
Exemestane, Formestane
araomatase irreversible (stane on) anatagonist…used for ER pos and metastatic cancer…lots of AE…more effective than serms but high risk of fractures
Progestin-Only OC
Norgestrel
Norethindrone
MPA (medroxyprogesterone acetate…injectable)
etonogestrel (implant)
will suppress GNRH pulses and responsiveness to GNRH…also inhibits ovulation and transport of egg and sperm
don’t use in liver dz, cancer, pregnancy
combined OC
EE/ Mestranol + progestin
mimicks E2 and progesterone in luteal phase and suppresses GnRH, LH and FSH…also inhibiting ovulation and transport of egg and sperm
don’t use in cancer
Mifpristone
Progesterone antagonist…used for abortion up to day 49
don’t use in ectopic preg, IUD..can cause bleeding, infections