Estrogens lecture Flashcards

1
Q

Ethinyl Estradiol

A

syntetic steroidal estrogen (increases HDL, clotting factors and dec bone resproption) used for OC, vag atrophy, acne, delayed puberty….don’t use in cancer patients, pregnant, or DVTs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

DES- (diethylstilbestrol

A

syntetic non-steroidal estrogen (increases HDL, clotting factors and dec bone resproption) used for OC, vag atrophy, acne, delayed puberty….don’t use in cancer patients, pregnant, or DVTs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

other steroidal estrogens

A

Mestranol, quinestrol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

other non-steroidal estrogens

A

chlorotrianisene, methallenestril

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Tamoxifen

A

ERant in breast (part agonist in bone and endometrium)..used for breast cancer…don’t use in DVT/ pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Clomiphene

A

ERant in hypo and pituitary (partial ovarian agonist)…used for infertility from ovulatory disorder…don’t use in pregnancy DVT, cancer ect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Raloxifene

A

ER agonist in bone, antagonist at uterus/ breast….used for osteoporosis (don’t use in preg/ DVT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Fulvestrant

A

full ER antagonist…for metastatic BRCA cancer… don’t use in pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Anastrozole/Letrozole

A

araomatase reversible comp anatagonist…used for ER pos and metastatic cancer…lots of AE…more effective than serms but high risk of fractures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Exemestane, Formestane

A

araomatase irreversible (stane on) anatagonist…used for ER pos and metastatic cancer…lots of AE…more effective than serms but high risk of fractures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Progestin-Only OC

A

Norgestrel
Norethindrone
MPA (medroxyprogesterone acetate…injectable)
etonogestrel (implant)
will suppress GNRH pulses and responsiveness to GNRH…also inhibits ovulation and transport of egg and sperm
don’t use in liver dz, cancer, pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

combined OC

A

EE/ Mestranol + progestin
mimicks E2 and progesterone in luteal phase and suppresses GnRH, LH and FSH…also inhibiting ovulation and transport of egg and sperm
don’t use in cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Mifpristone

A

Progesterone antagonist…used for abortion up to day 49

don’t use in ectopic preg, IUD..can cause bleeding, infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly