Androgens

Question 1

testosterone enanthate/ cypionate

Answer 1

replacement of testosterone produces male effects…indicated for hypogonadism
AE: jaundice syndrome BPH, prostate cancer, gynecomastia, acne
conta: breast/ prostate cancer

Question 2

Flutamide

Answer 2

MOA: comp inhib of dihydrotest and test receptor binding
ind: for prostate cancer and BPH
AE: hepatotoxicity, hematopoietic…general symptoms
contra: severe hepatic impairment

Question 3

spironolactone

Answer 3

comp inhib of dihydro and test receptor inding
indications: hirsuitism, hypertension, acne, cirrhosis, edema, hypokalemia
AE: hyperkalemic metabolic acidosis, renal (inhibits ald binding)…also gynecomastia, impotence, sex side effects

Question 4

Finasteride

Answer 4

inhibition of 5a reductase…conversion of test do dihydrotestosterone
for: BPH and alopecia
AE: hypo sexual side effects…