Hyperthyroidism Flashcards
What is hyperthyroidism?
Occurs 5x more in which gender
At what age range?
Hyperactivity of the thyroid gland with a sustained increase in production and release of thyroid hormones by thyroid gland
Women
20-40
There is a image on page 2 where it shows the stages of hypo and hyper
Most extreme
Thyrotoxicosis
Hyperthyroidism
Euthyroid
Hypothyroidism
Myxedema coma
What is the most common form of hyperthyroidism?
Notes
Other causes
- toxic modular goiter
- thyroditis
- excess iodine intake
- pituitary tumors
- thyroid cancer
Graves’ disease
What is Graves’ disease?
An autoimmune disease characterized by thyroid enlargement and excess thyroid hormone secretion
What is the pathophysiology of Graves’ disease?
Notes
- remissions and exacerbations regardless of treatment
- may progress to destruction of thyroid tissue
Antibodies to TSH receptor stimulate release of T3 and T4
- this leads to clinical manifestations of thyroxtocisosis
What is thyrotoxicosis ?
Results from
Physiologic effects/clinical syndrome of hyper metabolism
- results from increase circulating levels of T3 and T4
Does hyperthyroidism and thyrotoxicosis usually occur together?
Yes
What are precipitating factors that interact with Graves’ disease? (5)
Genetic
Iodine supply decrease
Infection
Stress
Smoking
Graves’ disease is about 80% of cases? True or false
True
What are clinical manifestations of hyperthyroidism? (3)
Give two examples on what to do for the last one and hearing what
Increase metabolism
Increase tissue sensitivity to stimulation of SNS
Goiter
- inspection
- auscultation hearing bruits & increase blood supply
What is the biggest manifestation for hyperthyroidism?
Which also means?
Notes
Exophthalmos - bilateral
- increase fat deposits and fluid
- eyeballs forced outward
- whites seen above iris
- eyelids do not always completely close
- diplopia possible
Ophthalmopathy
Abnormal eye appearance or function
Notes
Cardiovascular system
- systolic hypertension
- bounding rapid pulse, palpitation
- increase cardiac output
- cardiac hypertrophy
- systolic murmurs
- dysrthythmias ( A fib )
- angina
Notes
Respiratory system
- increase rr
- dyspnea on mild exertion
Notes
Gi system
- increase appetite and thrist
- weight loss
- diarrhea
- splenomegaly & hepatomegaly
Notes
Integumentary system
- warm, smooth moist skin
- thin brittle nails
- hair loss
- clubbing of fingers !!
- Palmer erythema
- fine, silky hair, premature graying
- diaphoresis !
- vitiligo !
Patients may also experience something called pre-tibial myxedma & acropachy climbing of the fingers and soft tissue swelling
Notes !
Notes
Musculoskeletal system
- fatigue
- muscle weakness
- proximal muscle wasting
- dependent edema
- osteoporosis
Notes
Nervous system
- nervousness, anxiety, fine tremors
- insomnia
- exhaustion
- lability of mood, delirium
- hyperreflexia of tendon reflexes
- inability to concentrate
- stupor,coma
Notes
Reproductive system
- menstrual irregularities
- amenorrhea
- decrease libido
- impotence
- gynecomastia in men
- decrease fertility
What are the overall clinical manifestations (5)
Intolerance to hear
Elevated basal temperature
Lid lag, stare
Eyelid retraction
Rapid speech