Hypertension, Atheroma and Thrombosis Flashcards
What is Conn’s Syndrome an excess of?
excess Aldosterone
What is Cushing’s Syndrome an excess of?
excess excess corticosteroid
What is Phaeochromocytoma an excess of?
noradrenaline
What can left hypertrophy cause?
Increased LV Load Poor perfusion Interstitial fibrosis Micro infarcts Diastolic dysfunction
What does subarachnoid haemorrhage involve rupture of?
Berry aneurysm
In maligant hypertension, what is the diastolic blood pressure?
> 130-140
What is papilloedema?
Swelling of optic disc
Hypertension and proteinuria during pregnancy suggests what?
pre-eclampsia
What does this describe: Narrowing of arterial lumen, reduced elasticity, reduced flow in systole, tissue ischaemia?
Arterial stenosis
What happens if aterial stenosis occurs in peripheral arteries?
Claudication and food/leg ischaemia
What does plaque rupture often trigger?
thrombosis
What does this describe: Splitting within the media by flowing blood?
arterial dissection
Which syndrome is a risk for arterial dissection?
Marfan’s
What is ischaemia the result of?
impaired vascular perfusion depriving the affected tissue of nutrients
Can ischaemia be reversed?
yes (depending on many factors)
What is infarction?
ischaemic necrosis (death) of a tissue or organ secondary to occlusion/reduction of the arterial supply or venous drainage
What are the 3 aspects of Virschow’s triad?
- Change in blood flow (stasis or turbulence)
- Change in coagulability (hypercoagulability)
- Change in vessel wall (endothelial damage)
What produces the EC matrix?
endothelial cell