Hypersisitive Flashcards
The types of hypersensitivity differs according to
Mechanism of tissue damage
In the 1st type of hypersensitivity the 1st exposure to an allergen lead to
Sensitization of must cells and basophils
What are preformed mediators
Histamine and plasma activating factor
What mediators are responsible for the symptoms during the late phase (type one)
leukotrienes and prostaglandins
In hypersensitivity type one, in what phase there’s recruitment of eosinophils and basophils
Late phase. Early phase is mainly mast cells
The recruitment of eosinophils and basophils causes
release of hydrolytic enzymes
True or false . Bronchial asthma is systemic type one hypersensitivity
F localized
True or false. Urticaria is localized type two hypersensitivity
False, type one
Management of anaphylactic shock
In EMERGENCY
Adrenaline, corticosteroids together with oxygen inhalation.
Antibody-dependent cell-mediated cytotoxicity (ADCC) through the action of
Nk
What type of hypersensitivity uses complement activation as a mechanism
Two
T or f
Drug reaction is an example of Type “II” hypersensitivity
T
complement activation is a mechanism in both type two and three
F or T
T
What is the effect of histamine on blood vessels
increase permeability
The main cell involved in hypersensitivity type four
Th1
In what type of hypersensitivity antibodies have no roles
4
Inf-y role is
activates macrophages
Th1 release………..
Cytokines
T or f
continual release of Th1 cytokines leads tp accumulation of large numbers of activated macrophages
T
Cause of granuloma
accumulation of large numbers of activated macrophages
Whats the aim of granuloma
ISOLATE pathogens that resist intracellular destruction
Granuloma is typically seen in aids patients
T
In what phase of type pne hypersensitivity, there is a release of hydrolytic enzymes
Late phase
The allergens of the localized form of type one hypersensitivity are widely distributed in nature
True or false
True
True or false
The systemic anaphylaxis only occurs on re-exposure to an allergen to which the
individual is previously sensitized
T
Diseases caused by seconed type of hypersensitivity are usually specific for a particular tissue
True
What type of hypersensitivity could lead to grave diseas
Type two
How to diagnois contact dermatitis
Skin patch test
Example of autoimmune diseases in type four hypersensitivity
Insulin dopendant diabetes
