Hypersensitivity Reactions (ACID)

Question 1

What are the hypersensitivity reactions?

Answer 1

Type I: anaphylactic
Type II: cytotoxic
Type III: immune complex
Type IV: delayed hypersensitivity

Question 2

With a type I reactions the antigen reacts with what?

Answer 2

IgE

Question 3

In a type I when an antigen reacts with IgE it causes what to occur?

Answer 3

Mast cells to release histamine, heparin

as seen in allergies and asthma

Question 4

When type II reactions occur what happens?

Answer 4

IgG and IgM destroy cells

Question 5

What diseases see a type II reaction?

Answer 5

Erythoblastosis fetalis
Acute transfusion reaction
Autoimmune hemolytic anemia
ITP
Graves Disease
Goodpasture syndrome
Myastenia gravis

Question 6

What occurs in a type III reaction?

Answer 6

IgG mediated immune complex triggers inflammation

Question 7

A type III reaction is seen where?

Answer 7

Serum sickness
SLE
RA
Post-streptococcal glomerulonephritis
Farmer's lung

Question 8

Type IV reactions are mediated by what?

Answer 8

T cells

Question 9

Type IV reactions are seen where?

Answer 9

Mantoux testing for TB
Touching poison ivy (contact dermatitis)
Chronic transplant rejection
Type I diabetes mellitus

Question 10

In type IV reaction what is NOT produced?

Answer 10

Antibodies