Hypersensitivity & Autoimmunity Flashcards
what are the antigens of MS?
myelin basic protein and proteolipid protein
what HS rxn is MS?
type IV
what is the antigen for grave’s disease?
thyroid stimulating hormone receptor
what HS rxn is graves?
type II
what is the antigen and consequence of subacute bacterial endocarditis?
- bacterial antigen
- glomerulonephritis
what HS rxn is subacute bacterial endocarditis (or anything else that causes glomerulonephritis?)
type III
how can you distinguish between goodpasture’s disease and regular glomerulonephritis?
“lumpy-bumpy” immunological test. regular glomerulonephritis is “lumpy-bumpy” but goodpasture’s is smooth
what is the antigen for mixed essential cryoglobulinemia?
rheumatoid factor IgG complexes
what type HS rxn and outcome of mixed essential cryoglobulinemia?
type III; systemic vasculitis
what’s the antigen for rheumatoid arthritis?
unknown synovial joint antigen
what type of HS rxn is rheumatoid arthritis?
type IV
what’s the antigen for myasthenia gravis?
acetylcholine receptor
what type of HS rxn is myasthenia gravis?
type II
what’s the antigen for pemphigus vulgaris and what’s the consequence?
epidermal cadherin; blistering of skin
what’s the HS rxn for pemphigus vulgaris?
type II
what are the antigens for systemic lupus erythromatosus and what are the consequences?
- DNA, histones, ribosomes, snRNP, scRNP
- glomerulonephritis, vasculitis, arthritis
what HS rxn is systemic lupus erythromatosus?
type III
what is the antigen of goodpastures syndrome?
non-collagenous domain of basement membrane of collagen type IV (lungs and kidneys)
what are the consequences of goodpastures?
glomerulonephritis and pulmonary hemorrhage!
what type of HS rxn is goodpastures?
type II
what is the antigen and consequence for type 1 diabetes?
pancreatic beta cell antigen; beta cell destruction
what type of HS rxn is type 1 diabetes?
type IV
what is the antigen for autoimmune hemolytic anemia and what is the consequence?
Rh blood group antigens; destruction of red blood cells
what type of HS rxn is autoimmune hemolytic anemia?
type II
what is the neonatal version of autoimmune hemolytic anemia?
erythroblastosis fetalis
what is the antigen and consequence for immune thrombocytopenia purpura?
platelet integrin gpIIb:gpIIIa; abnormal bleeding
what type of HS rxn is ITP?
type II
what is the antigen and consequence for acute rheumatic fever
- streptococcal cell wall antigens
- arthritis, myocarditis, scarring of heart valves
what type of HS rxn is acute rheumatic fever?
type II
what is the antigen and consequence of type 2 diabetes?
insulin receptor (antagonist); hyperglycemia
what is the antigen for hypoglycemia?
insulin receptor (agonist)
what type of HS rxn are type 2 diabetes and hypoglycemia?
type II
what’s a good example of a type I HS rxn?
food allergies; peanuts
what type of HS rxn is urticaria (hives)?
type II
what type of HS rxn is serum sickness?
type III
what type of HS rxn is poison ivy?
type IV
list the three transplant rejections and what HS rxns they are
- hyperacute (type II)
- chronic (type III)
- acute (type IV)
what type of HS rxn is sympathetic ophthalmia?
type IV ( i think ) Th1 cell mediated
mutations in AIRE gene causes?
- wide range of autoimmunity
- defective thymic deletion of autoreactive T cells
what is IPEX?
mutations in FOXP3+ on Treg cells
what disease is associated with the DQ2/DQ8 haplotypes?
- celiac disease
- type 1 diabetes
- coxsackie virus A/B
b27 haplotype?
- ankylosing spondylitis
- chlamydia trachomatis
- campylobacter jejuni
HLA-DR2/DR4?
borrelia burgdoferi —-> chronic arthritis in lyme disease
HLA for group A strep?
unknown; causes rheumatic fever
what is an autoimmune consequence of chlamydia?
reiter’s syndrome (arthritis)
what is the autoimmune consequence of coxsackie viruses?
type 1 diabetes
what is the autoimmune consequences of c. jejuni?
GBS and arthritis
the antigen MAGE-1 is found in what kind of cancer?
melanoma
what’s a tissue specific antigen found on normal and cancerous cell that produce melanin?
tyrosinase
what is CEA antigen?
oncofetal antigen for colon cancer (carcinoembryonic antigen)
what kind of cancer is alpha-fetoprotein found in?
liver and testes cancer
what is CALLA antigen or CD10?
common acute lymphoblastic leukemia antigen
what is PSA antigen?
prostate specific antigen
