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immunology > Hypersensitivity & Autoimmunity > Flashcards

Hypersensitivity & Autoimmunity Flashcards

1
Q

what are the antigens of MS?

A

myelin basic protein and proteolipid protein

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2
Q

what HS rxn is MS?

A

type IV

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3
Q

what is the antigen for grave’s disease?

A

thyroid stimulating hormone receptor

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4
Q

what HS rxn is graves?

A

type II

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5
Q

what is the antigen and consequence of subacute bacterial endocarditis?

A
  • bacterial antigen

- glomerulonephritis

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6
Q

what HS rxn is subacute bacterial endocarditis (or anything else that causes glomerulonephritis?)

A

type III

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7
Q

how can you distinguish between goodpasture’s disease and regular glomerulonephritis?

A

“lumpy-bumpy” immunological test. regular glomerulonephritis is “lumpy-bumpy” but goodpasture’s is smooth

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8
Q

what is the antigen for mixed essential cryoglobulinemia?

A

rheumatoid factor IgG complexes

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9
Q

what type HS rxn and outcome of mixed essential cryoglobulinemia?

A

type III; systemic vasculitis

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10
Q

what’s the antigen for rheumatoid arthritis?

A

unknown synovial joint antigen

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11
Q

what type of HS rxn is rheumatoid arthritis?

A

type IV

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12
Q

what’s the antigen for myasthenia gravis?

A

acetylcholine receptor

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13
Q

what type of HS rxn is myasthenia gravis?

A

type II

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14
Q

what’s the antigen for pemphigus vulgaris and what’s the consequence?

A

epidermal cadherin; blistering of skin

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15
Q

what’s the HS rxn for pemphigus vulgaris?

A

type II

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16
Q

what are the antigens for systemic lupus erythromatosus and what are the consequences?

A
  • DNA, histones, ribosomes, snRNP, scRNP

- glomerulonephritis, vasculitis, arthritis

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17
Q

what HS rxn is systemic lupus erythromatosus?

A

type III

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18
Q

what is the antigen of goodpastures syndrome?

A

non-collagenous domain of basement membrane of collagen type IV (lungs and kidneys)

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19
Q

what are the consequences of goodpastures?

A

glomerulonephritis and pulmonary hemorrhage!

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20
Q

what type of HS rxn is goodpastures?

A

type II

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21
Q

what is the antigen and consequence for type 1 diabetes?

A

pancreatic beta cell antigen; beta cell destruction

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22
Q

what type of HS rxn is type 1 diabetes?

A

type IV

23
Q

what is the antigen for autoimmune hemolytic anemia and what is the consequence?

A

Rh blood group antigens; destruction of red blood cells

24
Q

what type of HS rxn is autoimmune hemolytic anemia?

A

type II

25
Q

what is the neonatal version of autoimmune hemolytic anemia?

A

erythroblastosis fetalis

26
Q

what is the antigen and consequence for immune thrombocytopenia purpura?

A

platelet integrin gpIIb:gpIIIa; abnormal bleeding

27
Q

what type of HS rxn is ITP?

A

type II

28
Q

what is the antigen and consequence for acute rheumatic fever

A
  • streptococcal cell wall antigens

- arthritis, myocarditis, scarring of heart valves

29
Q

what type of HS rxn is acute rheumatic fever?

A

type II

30
Q

what is the antigen and consequence of type 2 diabetes?

A

insulin receptor (antagonist); hyperglycemia

31
Q

what is the antigen for hypoglycemia?

A

insulin receptor (agonist)

32
Q

what type of HS rxn are type 2 diabetes and hypoglycemia?

A

type II

33
Q

what’s a good example of a type I HS rxn?

A

food allergies; peanuts

34
Q

what type of HS rxn is urticaria (hives)?

A

type II

35
Q

what type of HS rxn is serum sickness?

A

type III

36
Q

what type of HS rxn is poison ivy?

A

type IV

37
Q

list the three transplant rejections and what HS rxns they are

A
  • hyperacute (type II)
  • chronic (type III)
  • acute (type IV)
38
Q

what type of HS rxn is sympathetic ophthalmia?

A

type IV ( i think ) Th1 cell mediated

39
Q

mutations in AIRE gene causes?

A
  • wide range of autoimmunity

- defective thymic deletion of autoreactive T cells

40
Q

what is IPEX?

A

mutations in FOXP3+ on Treg cells

41
Q

what disease is associated with the DQ2/DQ8 haplotypes?

A
  • celiac disease
  • type 1 diabetes
  • coxsackie virus A/B
42
Q

b27 haplotype?

A
  • ankylosing spondylitis
  • chlamydia trachomatis
  • campylobacter jejuni
43
Q

HLA-DR2/DR4?

A

borrelia burgdoferi —-> chronic arthritis in lyme disease

44
Q

HLA for group A strep?

A

unknown; causes rheumatic fever

45
Q

what is an autoimmune consequence of chlamydia?

A

reiter’s syndrome (arthritis)

46
Q

what is the autoimmune consequence of coxsackie viruses?

A

type 1 diabetes

47
Q

what is the autoimmune consequences of c. jejuni?

A

GBS and arthritis

48
Q

the antigen MAGE-1 is found in what kind of cancer?

A

melanoma

49
Q

what’s a tissue specific antigen found on normal and cancerous cell that produce melanin?

A

tyrosinase

50
Q

what is CEA antigen?

A

oncofetal antigen for colon cancer (carcinoembryonic antigen)

51
Q

what kind of cancer is alpha-fetoprotein found in?

A

liver and testes cancer

52
Q

what is CALLA antigen or CD10?

A

common acute lymphoblastic leukemia antigen

53
Q

what is PSA antigen?

A

prostate specific antigen

immunology (9 decks)

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