compliment

Question 1

what activates the classical pathway

Answer 1

IgG and IgM antigen-antibody complexes (C1,2,4 > C3 > C5)

Question 2

what activates the lectin pathway

Answer 2

microbial surface - mannan binding lectin C2

Question 3

what activates the alternative pathway

Answer 3

microbial surface - ENDOTOXIN. C3 hydrolyzes to C3bBb = C3 convertase

Question 4

C1, 2, 3, 4

Answer 4

viral neutralization

Question 5

C3b

Answer 5

opsinization, immune complex clearance

Question 6

what mediates immune complex clearance?

Answer 6

C3b

Question 7

which 2 factors prevent complement activation on self cells

Answer 7

DAF and C1 esterase

Question 8

C3a, C5a

Answer 8

anaphylaxis. mast and basophil degranulation

Question 9

C5b-9

Answer 9

MAC

Question 10

C1 esterase deficiency

Answer 10

hereditary angioedema (prevents activation on self-cells)

Question 11

C3 deficiency

Answer 11

Pyogenic sinus/resp tract infections. more susceptible to type III Hypersensitivity - impaired immune complex clearance

Question 12

C5-8 deficiency

Answer 12

Niesseria bacteremia

Question 13

DAF deficiency

Answer 13

PNH (GPI-anchored enzyme)