Hypersensitivity

Question 1

what immunoglobulin is involved in;

• type I hypersensitivity
• type II
• type III

Answer 1

type I = IgE
type II = IgG or IgM
type III = IgG

Question 2

what antibodies are involved in rheumatoid arthritis?

what type of hypersensitivity is this?

Answer 2

delayed hypersensitivity - type IV
rheumatoid factor
anti-CCP

Question 3

what type of hypersensitivity reaction is a blood transfusion reaction? What immunoglobulin is it medicated by?

Answer 3

IgM

type II / antibody mediated hypersensitivity reaction

Question 4

what type of hypersensivity reaction is graves disease? what is the B cell and T cell involvement?

Answer 4

type II / antibody mediated hypersensitivity reaction
IgG (B-cell)
Th1 (T-cell)

Question 5

what type of hypersensivity reaction is SLE?

what auto-antibodies are involved in SLE?

Answer 5

immune complex mediated / type III hypersensitivity reaction

anit- DsDNA, anti-Ro, anti-Smith

Question 6

what innate cells are involved in type 1 hypersensitivity reactions?

Answer 6

mast cells

eosinophils

Question 7

what innate cells are involved in a type II hypersensitivity reaction?

Answer 7

phagocytes

Question 8

what innate cells are involved in type III hypersensitivity reaction?

Answer 8

neutrophils

Question 9

what adaptive immune cells are activated in type IV hypersensitivity reactions?

Answer 9

CD 4 - (Th1 and Th17 cells).
CD 8 (cytotoxic lymphocytes)