Hypersensitivity

Question 1

3 triggers of hypersensitivity

Answer 1

self antigens
excess inflammation from microbes
allergies or environmental antigens

Question 2

Type I hypersensitivity timing and antibody

Answer 2

immediate, affiliated with IgE and eosinophils

Question 3

Type I hypersensitivity mediators

Answer 3

vasoactive mediators, lipid mediators and cytokines

Question 4

Most common type of Type 1 hypersensitivity

Answer 4

allergies…histamine response

food drug environment

Question 5

Type II and III hypersensitivity antibodies

Answer 5

IgG and IgM, these are usually auto antibodies

Question 6

Type II hypersensitivity description of mechanism

Answer 6

IgG/M auto antibodies commonly against specific tissue types or ECM, the antibodies directly bind the target and lead to localized symptoms

Question 7

Type III hypersensitivity description of mechanism

Answer 7

IgG/M antibodies bind material in blood usually and form immune complexes…these can then deposit and lead to systemic issues

Question 8

Types of issues with Type II hypersensitivity antibodies binding

Answer 8

opsonization/phagocytosis induced of cells that are not bad, complement and Fc receptor inflammation, receptor activation (graves disease)

Question 9

Good pasture/anti-glomerular basement membrane disease mechanism and symptoms

Answer 9

Antibodies againts basement membrane of kidneys and lung…activates Fc receptors and fixes complement

fatigue, bloody urine, bloody lung, kidney failure

type II hypersensitivity

Question 10

idiopathic thrombocytopenic purpura disease and type of HyperSensitivity

Answer 10

antibodies against own platelets leading to opsonization and phagocytosis ….type II

Question 11

Autoimmune hemolytic anemia disease and type of hypersensitivity

Answer 11

auto antibodies against RBCs membrane proteins…leads to anemia

type II

Question 12

Graves disease information and type of hypersensitivity

Answer 12

autoantibody against the thyroid TSH receptor and actually activates when it binds..leading to too much thyroid hormone

type II

Question 13

myasthenia gravis disease information and type of hypersensitivity

Answer 13

antibody binds the acetylcholine receptor in muscular synapse and prevents acetylcholine from binding…leads to problems with muscle contraction

type II

Question 14

acute rheumatic fever disease and type of hypersensitivity

Answer 14

autoantibodies against myocardial

Type II

Question 15

pemphigus vulgaris disease and type of hypersensitivity

Answer 15

autoantibodies against desmosomes

type II

Question 16

pernicious anemia disease and type of hypersensitivity

Answer 16

autoantibodies against intrinsic factor

type II

Question 17

Type III hypersensitivity timing

Answer 17

3-10 hours till onset

Question 18

Type III hypersensitivity physiologic issues

Answer 18

complement and Fc receptor activation leads to recruitment of inflammatory cells…complement induces serious anaphylaxis and can cause histamine release

VASCULITIS

Question 19

Common type III hypersensitivity symptoms

Answer 19

joint pain, fever, hives

Question 20

Serum Sickness disorder and type of hypersensitivity

Answer 20

antibodies against horse serum and sometimes drugs…leads to immune complexes that cause symptoms of….type III hypersensitivity

Question 21

systemic lupus type of hypersensitivity and associated symptoms

Answer 21

type II and III
vasculitis and arthritis for Type III
anti nuclear antibodies type II

Question 22

Type IV hypersensitivity mechanism and timing

Answer 22

through T cells cytokines CD4 and CD8

1-3 days response

mainly dermatitis

Question 23

PPD test type of hypersensitivity?

Answer 23

type IV cd4

Question 24

poison ivy type of hypersensitivity?

Answer 24

type IV cd8

Question 25

poison ivy mechanism of infection and treatment

Answer 25

urushiol is lipid and enters cells, then presentedby MHC I and the CD8 cells destroy

best treatment is to immediately wash skin so the oil does no spread then steroids