Hypersensitivity Flashcards
These are environmental antigens that typically elicits allergic responses in susceptible individuals
Allergens
What are the AEROALLERGENS?
Pollens
Mold Spores
Animal Dander
Fecal material excreted by mites
Cockroaches
Clinically adverse reflecting acquired immune response that are marked PHENOTYPICALLY.
Allergy
It is an acute, generalized allergic reaction with simultaneous involvement of several organ systems, usually CARDIOVASCULAR, RESPIRATORY, CUTANEOUS, AND GASTROINTESTINAL.
Anaphylaxis
Ana:_____;Phylaxis:_____
Ana: Opposite
Phylaxis: Protection
refers to Anaphylaxis in which HYPOTENSION, with or without loss of consciousness.
Anaphylactic shock
It is a condition in which the symptoms and signs of anaphylaxis occur in the ABSENCE OF AN ALLERGEN-ANTIBODY MECHANISM.
Anaphylactoid Reaction
another term for allergy
Atopy
In Atopy, a word meaning “strange disease” derived from the Greek for “_______”.
out of place
____ of activated mast cells, basophils, and eosinophils release preformed primary mediators.
Degranulation
In Degranulation, What are the preformed primary mediators?
Heparin
Histamine
Protease
Eosinophil chemotactic factor
Neutrophil chemotactic factor
is a process of temporarily supressing immediate HYPERSENSITIVITY reactions by repeated injections of increasing amounts of the offending allergens
Desensitization
can be defined as a NORMAL but EXAGGERATED/UNCONTROLLED immune response go an antigen that can produce inflammation,. cell destruction, or tissue injury.
Hypersensitivity
It is the basis of ACUTE ALLERGIC REACTIONS caused by molecules released by mast cells when an allergen interacts with membrane-bound IgE.
Immediate Hypersensitivity
It is often used synonymously with the term cell-mediated immunity
Delayed Hypersensitivity
a PRIMARY immune response to an antigen and has no clinical consequences
Sensitization stage
A SECONDARY immune response that id deleterious to the individual.
Effector Stage
Distinguish Humoral hypersensitivities from cellular hypersensitivities
Older classification
Characteristic :(Response time following challenge dose of antigen)
“Gradually rises to peak at 24-72hrs”
Delayed Hypersensitivity
Characteristic :(Responsible cellular and chemical agents)
“ B cell product”
Immediate Hypersensitivity
Characteristic :(Response time following challenge dose of antigen)
“Visible within minutes; diminished within few hours”
Immediate Hypersensitivity
Characteristic :(Responsible cellular and chemical agents)
“T cell product”
Delayed Hypersensitivity
Characteristic: (Passive transfer via)
“SERUM”
Immediate hypersensitivity
Characteristic: (Passive transfer via)
“T Lymphocytes”
Delayed Hypersensitivity
Characteristic: (Chemotherapy)
“Steroids”
Delayed Hypersensitivity
Characteristic: (Chemotherapy)
“Antihistamine and Adrenergenic compounds”
Immediate Hypersensitivity
Characteristic :(Target tissues)
“Primarily smooth muscles; organs; vascular tissue”
Immediate Hypersensitivity
Characteristic:(Target tissue)
“No special targets; generalized response”
Delayed Hypersensitivity
Characteristic:(Histology of skin response)
“Erythema, Edema, and Wheal Formation; granulocytes predominate in early response; mononuclear cells increase in later response”
Immediate Hypersensitivity
Characteristic:(Histology of skin response)
“Erythema and Induration; little edema; no wheal; mononuclear cells predominate”
Delayed Hypersensitivity
Characteristic:(Tissue Death)
“Common”
Immediate Hypersensitivity
Characteristic:(Tissue Death)
“Uncommon”
Delayed Hypersensitivity
Characteristic:(Relative ease of desensitization)
“Easy: via formation of blocking antibodies”
Immediate Hypersensitivity
Characteristic:(Relative ease of desensitization)
“Difficult: mechanism unknown”
Delayed Hypersensitivity
Newer system which consists of four categories emphasizing the kind of immunopathological damage incurred.
Gell and Coombs Classification
In Gell and Coombs Classification, What type are mainly immunoglobulin-mediated?
Type I,II,III
In Gell and Coombs Classification, What Type is mediated by T cells and is synonymous with delayed hypersensitivity.
Type IV
In Gell and Coombs Classification, What type is also called Immediate Hypersensitivity?
Type I
In Gell and Coombs Classification, What type reaction ade initiated by the binding of antibody to a cell membrane or to the extracellular matrix.
Type II
In Gell and Coombs Classification,What type hypersensitivity reaction involve the interaction of antibodies with soluble molecules to make soluble antigen-antibody complexes.
Type III
In Gell and Coombs Classification, What type of hypersensitivity reaction are those in which cells of the immune system directly attack host cell in the absence of antibody.
Type IV
What atopic reaction that is called anaphylaxis and affects the entire body?
systemic atopic response
What Atopic reaction is the allergic symptoms depend on the anatomic location?
Local atopic reaction
