Hypersensitivities and Immunopathologies

Question 1

** Type I HS involves _________ antibodies

Answer 1

IgE

Question 2

** Type II HS involves _________ antibodies (2)

Answer 2

IgM

IgG

Question 3

** Type III HS involves _________ antibodies (2)

Answer 3

IgM

IgG

Question 4

** Type IV HS involves _________ cells

Answer 4

T cells

Question 5

Which type of HS is ANTIBODY mediated?

Answer 5

Type II

Question 6

Which Type of HS is IMMEDIATE (allergic)?

Answer 6

Type I

Question 7

Which type of HS is IMMUNE COMPLEX mediated?

Answer 7

Type III

Question 8

Which type of HS is CELL mediated?

Answer 8

Type IV

Question 9

** ALL forms of HS require _________

Answer 9

prior exposure to the antigen

Question 10

HS can target SELF antigens OR FOREIGN antigens

T/F

Answer 10

True

Question 11

** Type I HS is associated with _________

Answer 11

allergies

Question 12

About _________ of the population suffers from type I HS

Answer 12

54%

Question 13

In type I HS, Helper T cells are activated and differentiate to the _________ subtype

Answer 13

Th2

Question 14

APC presents peptide to the allergen on _________ molecules in Type I HS

Answer 14

MHC II

Question 15

In type I HS, IgE antibodies that are attached to _________ have a half life of several weeks

Answer 15

mast cells

Question 16

_________ associated with ALLERGIES are located in the tissues and have receptors for the Fc region of IgE

Answer 16

mast cells

Question 17

In allergies, _________ are brought into the tissue from the blood by signals sent by the MAST CELLS for RAPID release

Answer 17

basophils

Question 18

In allergies, _________ are recruited from the BONE MARROW and have a DELAYED response

Answer 18

eosinophils

Question 19

People who are _________ produce large quantities of IgE

Answer 19

atopic

Question 20

People who are NON-Atopic produce mainly _________ antibodies

Answer 20

IgG

Question 21

Type II HS does NOT involve _________ antibodies

Answer 21

IgE

involves IgG and IgM

Question 22

Antibody dependent cell-mediated cytotoxicity (ADCC) is associated with _________ HS

Answer 22

Type II

Question 23

ADCC cells (type II HS) are COMPLEMENT _________

Answer 23

independent

Question 24

In type II HS, _________ and _________ antibodies are good at FIXING THE COMPLEMENT

Answer 24

IgM
IgG

(Me Good at fixing complement)

Question 25

In type II HS, antibodies bind to carbs or proteins present on RBCs that are PHAGOCYTIZED, this is known as _________

Answer 25

hemolytic anemias

Question 26

RHEUMATIC HEART DISEASE where streptococcal throat infection activated Helper T cells is an example of _________ HS

Answer 26

Type II

Question 27

** Deposition of antibodies and antigen complexes causing INFLAMMATION (vasculitis) is associated with _________ HS

Answer 27

Type III

Question 28

In type III HS, complement attracts _________ and _________

Answer 28

neutrophils

macrophages

Question 29

LUPAS is an INFLAMMATORY disease which is usually (90%) found in women that exhibits B and T cell INTOLERANCE and is an example of _________ HS

Answer 29

Type III

Question 30

Delayed Type Hypersensitivity (DTH) and Cell Mediated Cytotoxicity are two types of _________ HS

Answer 30

type IV

Question 31

Type IV HS does NOT involve _________

Answer 31

antibodies

involves T cells

Question 32

** Caron’s Disease, Type I Diabetes, CONTACT DERMATITIS, and MULTIPLE SCLEROSIS are associated with _________ HS (2)

Answer 32

Type IV

Question 33

MULTIPLE SCLEROSIS is an example of _________ HS where self-reactive T cells target myelin basic protein

Answer 33

Type IV

Question 34

** Autoimmune hemolytic anemia, and MYASTHENIA GRAVES are all associated with _________ HS

Answer 34

Type II

Question 35

** Poison ivy (DTH), chronic transplant rejection, type I diabetes, and MS are all associated with _________ HS

Answer 35

Type IV

Question 36

** Lupas and Rheumatoid Arthritis are associated with _________ HS

Answer 36

Type III

Question 37

** Inappropriate or excessive immune responses from T cells are associated with _________ HS

Answer 37

Type IV

Question 38

** In _________ HS, the antigen may be yours OR it may be from exogenous molecules like DRUGS

Answer 38

type II

Question 39

** In _________ HS, INFLAMMATION takes place at the sites of DEPOSITION

Answer 39

type III