Cancer and the Immune System

Question 1

Cancer is the number 2 death behind _________

Answer 1

cardiovascular disease

Question 2

A particular gene that when mutated can cause a cell to proliferate inappropriately is known as a _________

Answer 2

proto-oncogene

Question 3

A mutated version of a photo-oncogene is known as an _________

Answer 3

oncogene

Question 4

Between _________ and _________ mutations are required to produce most common cancers

Answer 4

4-7

Question 5

Liver cancer is associated with chronic _________ in 20% of cases

Answer 5

hepatitis B

Question 6

** VIRAL infections contribute to _________ of all human cancers

Answer 6

15-20%

Question 7

** In people with cancer, higher _________ counts are associated with longer survival

Answer 7

lymphocyte

Question 8

CTLs are probably MORE effective in _________ cells than in SPONTANEOUS TUMORS

Answer 8

cancerous blood (cells)

Question 9

Some cancerous blood cells express high levels of _________

Answer 9

B7

Question 10

** _________ may provide SURVEILLANCE against some cancers by preventing ANGIOGENESIS

Answer 10

macrophages

Question 11

** In vitro, _________ cells can destroy some cancer cells

Answer 11

NK cells

Question 12

Vaccination can be used in _________ associated cancers like Hep B/Liver cancer and HPV/Cervical cancer

Answer 12

virally (associated CA)

Question 13

** _________ is a manufactured ANTIBODY that TARGETS a protein called PD-L1

Answer 13

MPDL320A

Question 14

** _________ is found on the SURFACE of many CANCER cells and IMPAIRS the immune system’s ability to FIGHT the disease

Answer 14

PD-L1

Question 15

Injecting a tumor with _________ which hyper activates macrophages can destroy a tumor

Answer 15

Bacille Calmette-Guerin (BCG)