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Immuno Final > Hypersensitivies And Immunopathologies > Flashcards

Hypersensitivies And Immunopathologies Flashcards

1
Q

MS is associated with what specific hypersensitivity reaction?

A

T cell mediated cytotoxicity

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2
Q

What is the theory that the rise in chronic inflammatory disease, especially allergies and asthma is an unintended consequence of a reduction in exposure to microbes in the first year of life?

A

Hygiene hypothesis

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3
Q

What type of hypersensitivity reaction occurs within minutes or hours?

A

Type I

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4
Q

How is TB contracted?

A

Airborne infection

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5
Q

Cell mediated cytotoxicity is mediated by what?

A

CD8 killer T cells

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6
Q

What is the “anti onco” gene that prevents tumors?

A

TP53

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7
Q

What type of hypersensitivity reaction uses T cells?

A

Type IV

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8
Q

What is released by mast cells in the early phase?

A

Vasoactive amines (histamine), proteases, prostaglandins

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9
Q

What condition is caused by defects in immune regulation ?

A

Allergy

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10
Q

What is the number 2 cause of death?

A

Cancer

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11
Q

What are pathologic conditions caused by a normal immune response?

A

TB sepsis

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12
Q

What gene is an accident waiting to happen?

A

Proto-oncogene

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13
Q

In vitro what cells can destroy some cancer cells?

A

NK cells

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14
Q

Lupus and Rheumatoid arthritis are associated with what type of hypersensitivity ?

A

Type III

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15
Q

What is a mutated chromosome 22 called?

A

Philadelphia chromosome

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16
Q

Will someone always have an initial allergic reaction to the first exposure?

A

No, it takes a while for the IgE antibodies to accumulate

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17
Q

What hypersensitivity reaction is antibody mediated but depend on complement to do the killing?

A

TYPE II

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18
Q

What cells response is delayed during an allergic reaction?

A

Eosinophils

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19
Q

MS is initiated by what?

A

Self reactive T cells

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20
Q

What type of hypersensitivity reaction is known as allergies?

A

Type I

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21
Q

How many mutations are required to produce cancer?

A

4-7

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22
Q

What type of hypersensitivity is stimulated by intracellular parasites?

A

Type IV

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23
Q

Secondary exposure to an allergen will activate what cells?

A

Mast cells

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24
Q

What is MPDL3280A

A

Manufactured antibody that targets a progestin called PD-L1

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25
Q

What is the observation of both tumor inhibiting and tumor enchanting process mediated by the immune system?

A

Immunoediting hypothesis

26
Q

What is it called when lymphocytes attack non self and SELF?

A

Molecular mimicry

27
Q

Which type of hypersensitivity reaction is immediate?

A

Type I

28
Q

What hypersensitivity reaction is antibody mediated?

A

Type II

29
Q

During an allergic reaction what cells are recruited from bone marrow (t helper secreting IL-5) ?

A

Eosinophils

30
Q

Do hypersensitivity reactions target self antigens or foreign antigen ?

A

Either or

31
Q

The Philadelphia chromosome is associated with what?

A

Chronic myeloid leukemia

32
Q

Is ADCC complement independent or dependent?

A

Independent

33
Q

What does most of the damage in MS?

A

Macrophages

34
Q

Hypersensitivity is when the immune response to the antigen is _______or________?

A

Excessive or inappropriate

35
Q

Lupus erythematosus is what cell intolerance ??

A

B AND T CELL INTOLERANCE

36
Q

What specific named reaction is associated with Type III hypersensitivity?

A

Arthus reaction

37
Q

HIV-1 infects what cells?

A

Help T cells

38
Q

What type of hypersensitivity reaction is associated with inflammation?

A

Type III

39
Q

What type of hypersensitivity does not involve antibodies?

A

Type IV

40
Q

What cells during an allergic reaction have an immediate response ?

A

MAST cells

41
Q

Non atopic people produce mainly what antibody?

A

IgG

42
Q

Poison ivy is associated with what hypersensitivity ?

A

Type IV (DTH)

43
Q

What is an example of an immunodeficiency ?

A

Genetic deficiency and AIDS

44
Q

What causes allergies?

A

Overproduction of IgE antibodies

45
Q

What type of hypersensitivity reaction uses IgE

A

Type I

46
Q

What cells also have receptors for IgE and will DEGRANULATE upon antigen exposure

A

Basophils

47
Q

During pregnancy the mom has a strong bias towards what?

A

Th2

48
Q

Lupus is more common in who?

A

Woman, in lungs joints, kidneys

49
Q

What interleukin is associated with class switching?

A

IL4

50
Q

What is released by mast cells in the late phase?

A

IL-4, and TNF

51
Q

Allergies are associated with what kind of bias?

A

Th2

52
Q

What type of hypersensitivity reaction is CELL mediated ?

A

Type IV

53
Q

What type of hypersensitivity reaction is immune complex mediated?

A

Type III

54
Q

What antibodies are good at fixing complement?

A

IgM and IgG

55
Q

Delayed type hypersensitivity is mediated by what?

A

CD4 helper t cells

56
Q

What hypersensitivty reaction is when antibody antigen complexes accumulate, deposit in tissues and cause inflammation ?

A

Type III

57
Q

What type of hypersensitivity reaction uses IgM and or IgG?

A

Type II

58
Q

What cytokine is assocaited with Sepsis?

A

TNF

59
Q

What type of hypersensitivity reaction uses IgM and or IgG?

A

Type III

60
Q

What are examples of functional derangements?

A

Myasthenia gravis, pernicious anemia, graves disease.

Immuno Final (5 decks)

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