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Immuno Final > Cancer > Flashcards

Cancer Flashcards

1
Q

Cancer arises when multiple controls systems are corrupted within__________?

A

A single cell

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2
Q

What gene is an accident waiting to happen ?

A

Proto oncogene

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3
Q

What is an oncogen ?

A

Mutated

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4
Q

What gene is the anti oncogene?

A

TP53

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5
Q

How many mutations are required for most cancers?>

A

4-7

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6
Q

The philadelphia chromosome is associated with what?

A

Chronic myeloid leukemia

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7
Q

What chromosome is known as the Philadelphia chromosome ?

A

22

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8
Q

HHv-8 + AIDS =

A

Karpsi sarcoma

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9
Q

HPV = what cancer ?

A

Cervical

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10
Q

Liver cancer =

A

Chronic hep B

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11
Q

What is the overseeing of both tumor inhabiting and tumor enhancingc processes mediated by the immune system ?

A

Immunoediting hypothesis

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12
Q

Can hyperacticated macrophages kill cancer?

A

Yes via, TNF

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13
Q

In Vivo what cell can be effective against cancer?

A

NK cells

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14
Q

N1 phenotype =

A

Antitumorigenic

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15
Q

N2 phenotype =

A

Pro tumorigenic

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16
Q

What protein in rats is deficient making them more Likely to developed tumors?

A

RAG-2

17
Q

How can cancer cells disable CTLs?

A

Express high levels of indoleamine 2,3 deoxygenase

18
Q

In what kind of cancer are vaccines used to prevent it?

A

Viral (hep b, HPV)

19
Q

What is associated with the immune checkpoint blockade ?

A

Yervoy (ipillimumab) and the CTLA-4 receptor

20
Q

What is MPDL3280A ?

A

Immune therapy against cancer that targets protein called PD-L1

21
Q

What are infections of step that cause regression of sarcoma?

A

Coleys toxins

22
Q

Injecting what will cause macrophages to become hyperactive which will destroy tumors?

A

Bacille Calmette-guerin (BCG

Immuno Final (5 decks)

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