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Immuno Final > Immune System Dysreg > Flashcards

Immune System Dysreg Flashcards

1
Q

What pathologies are caused by a normal condition ?

A

Tb, sepsis

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2
Q

What conditions caused by defects in the immune regulation?

A

Allergy

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3
Q

What are diseases that are immunodeficiency ?

A

AIDS, genetic deficiency

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4
Q

Molecular mimicry is associated with what?

A

Autoimmune disease

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5
Q

How is TB contracted ?

A

Airborne infection

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6
Q

When TB organism is inhaled it is engulfed by what?

A

Alveolar macrophages (dust cells)

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7
Q

What does vitamin D release that increase antimicrobial activity against TB?

A

Cathelicidins

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8
Q

What is a potentially life threating complication of an infection?

A

Sepsis

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9
Q

Sepsis occurs when chemicals released into the blood to wfight the infection trigger what?

A

Inflammation throughout the body

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10
Q

What cytokine is associated with sepsis?

A

TNF

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11
Q

In sepsis TNF does what to vascular permeability and blood volume and BP?

A

Decreases, causing septic shock and heart failure

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12
Q

In sepsis vagal stimulation decreases what?

A

Macrophage release of TNF

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13
Q

Allergies are associated with a bias towards what?

A

Th2

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14
Q

Non allergic people produce what antibody and have what kind of bias?

A

IgG and Th1

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15
Q

People with an allergy produce large quantities of what and have what bias?

A

IgE and Th2

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16
Q

Fc end of IgE binds to what?

A

Mast cells

17
Q

Fab end of IgE binds to allergen which triggers what?

A

Mast cell to degranulation

18
Q

What interleukin can recruit many eosinophils from bone marrow ?

A

IL-5

19
Q

What acts as a guidance system for mast cells basophils and eosinophils?

A

IgE

20
Q

The placenta produces large quantities of what?

A

IL-4

21
Q

Is it better for the fetus to be bias towards Th1 or Th2?

A

Th2

22
Q

What activates NK cells?

A

TNF

23
Q

What is the theory that the use of chronic inflammation diseases, especially allergies and asthma, is an unintended consequence of a reduction in exposure to microbes in the first years of life?

A

Hygiene hypothesis

24
Q

People who are atopic are more likely to have inherited what genes?

A

Class II MCH

25
Q

What blocks the binding of IgE to mast cells?

A

Xolair

26
Q

What interleukin are associated with Th2?

A

IL-4, IL-5, IL-13

27
Q

What is an immune system attack on myelin in PNS?

A

Gillian barre

28
Q

What is an inflammatory process of the spinal cord, and can cause axon demyelination?

A

Transverse myelitis

Immuno Final (5 decks)

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