Hydroxychloroquine

Question 1

Hydroxychloroquine

Answer 1

Antimalarials MOA

Question 2

Hydroxychloroquine Action

Answer 2

Antiflammitory

Suppresses immune system

Accumulates in WBC’s stabilizing lysosomal membranes and inhibiting enzymes such as collagenase that causes cartilage breakdown

Inhibiting toll-like receptors (TLR’s)

Slows progression of RA

Question 3

Hydroxychloroquine Use

Answer 3

Analgesia reduce joint swelling, pain

Maintenance of joint function

Organ Rejection

RA Pain and Stiffness

Question 4

Hydroxychloroquine Dosage

Answer 4

Initial: 400-600mg daily in a single dose or 2 equally divided doses

Maintenance: 200mg/daily

Question 5

Hydroxychloroquine Contraindications

Answer 5

Hypersensitive to Medication

other 4-aminoquinoline compounds

Question 6

Hydroxychloroquine Interactions

Answer 6

Ampicillin

Antacids

Digoxin

Hepatotoxic or Nephrotoxic drugs

Question 7

Hydroxychloroquine Education

Answer 7

Take w/ Meals

Take as prescribed

Possible Visual reactions such as halos, blurred vision (need frequent eye exams)

Notify provider in muscle weakness develops

Keep drug out of reach from children

Avoid alcohol

Educate oncompliance and adherence as treatment regiment can be six months or greater

May have increased sensitivity to light-wear sunglasses

Question 8

Hydroxychloroquine Complications

Answer 8

Anxiety

bleeding gums

blindness

blistering, peeling, loosening of the skin

blood in the urine or stools

blurred vision or other vision changes