HY from MS lecture Flashcards
what Is Uhthoff’s phenomemon?
MS symtpoms that worsen during an increase in body temperature b/c of poor electrical conduction along demyelinated axons.
what is a relapse?
new neurologic disability that lasts greater than 24 hours.
may be reccurence of an old symptom: loss of vision in same eye twice, separated by an year.
maybr new symptom. weakness and numbness of both legs
SUBACUTE
2 lab findings consistent with MS dx?
IgG index and oligoclonal bands
neutrophils present in MS?
NO
why does gadalonium enter MS plaque?
b/c active inflammatio and breakdown of BBB –> allows gadolinium to enter brain parenchyma
bands of IgG of similar molecular weight =
oligoclonal bands
location of MS plaques?
periventricular and juxtacortical
what stain stains myelin blue?
luxol
demyelination shows up as white
MS pathogenesis?
genetic predisposition —> demyelination –> axonal loss
which type of MS more common in women?
equal in men and women?
relapsing remitting = MC in women
progressive = gender distribution equal
typical relapsing MS pt?
15-45 yr old woman who lives far from equator
describes what:
exacerbations followed by complete recovery
slow, inconsistent accumulation of disabilty
relapsing remitting MS
describes what:
develop spastic parapareis over a period of years
on exam have coritcospinal dysfunction(spasticity, weaknesss) sensory disturbance w/ urinar symptoms = long tract CNS symptoms
progressive forms of MS ( steady progression w/few or no exacerbations)
what does CSF of progressive MS pt look like?
just like relapsing-remitting MS, yet they never relapsed.
50% of MS pts need what in 15 years>
walking aids
what is found on spinal TAp of MS pt?
elevated Myelin basic protei nand OLIGOCLONAL banding
what are the four most common symptomsm that MS patients experience?
1. optic neuritis - unilateral, retrobulbar apin, no retinal exudates, disc hemorrhage infreqeunt, some recovery
2. myellitis (partial sensory > motor, band like pressure, Lhermmitte’s sign, bowel and bladder sx are common, acute dystonia)
3. brain stem- CN3 probs(Intranuclear opthalmoplegia and nyastagmus), trigeminal neuralgia, hemifacial spams, Bell’s palsy, vestibulopathy, and other cranial neuropathies.
**4. Cerebellar ataxia, tremor, eye movement probs **
MS symptoms acute or subacute?
subacute.