HY 5/ Flashcards
Sleep terror disorder is a parasomnia characterized by sudden arousals during the night associated with screaming and crying. These occur during the deepest stage of non-rapid eye movement (NREM) sleep. Unlike nightmares, the child is confused, disoriented, and unresponsive during these periods of arousal and has no memory of the episode when he wakes up in the morning. Safety measures and behavioral techniques such as scheduled awakenings are the first-line treatments for sleep terrors, but ___ can be used in severe and refractory cases.
Clonazepam
___ is the ability of a drug to treat whatever condition it is indicated for.
Efficacy
___ is how well the drug works in the real world. ___ encompasses a drug’s efficacy (the ability of the drug to treat whatever condition it is indicated for), but also its ease of use and tolerability. A drug may be efficacious (has ability to treat condition indicated for) but have so many adverse effects and its dosing schedule so complex that its ___ could be poor.
Effectiveness
Precocious puberty is defined as sexual development at age 8 years for girls and 9 years for boys. Most cases of precocious puberty are ___ in nature. Idiopathic or central precocious puberty is due to early activation of normal hypothalamic GnRH production. Laboratory results show elevated levels of GnRH, FSH, LH, and estrogen.
idiopathic
According to Piaget, newborn babies have a small number of ___ schemas that are the cognitive structures underlying the innate reflexes and are genetically programmed. Piaget called the schema the building blocks of intelligent behavior. These ___ schemas include sucking, grasping, and rooting.
innate
___ bias occurs in trials in which the knowledge about what intervention is being given to the participants is known. It can be reduced by blinding the subjects as well as the researchers.
Ascertainment
Studies have generally found that children typically come to understand the irreversibility, finality (or nonfunctionality), and universality of death between ___ years of age.
5 and 7
There is an increase in the ___ dopamine activity and turnover reaching peak of a lifetime, which is associated with less inhibitory control in adolescents. There is a decrease in the gray matter of adolescent’s brain during development throughout the cerebral cortex due to synaptic pruning. This has been linked with more risk-taking behavior in adolescents. There is also concomitant increase in the white matter in the cortical and subcortical fiber tracts from increased myelination and axon caliber, which is linked with more impulsive behavior. Some areas work to increase although overall still areas where limited but none where it is eliminated There is an increase in the D1 and D2 dopamine receptors in the striatum reaching peak density of a lifetime in early adolescence associated with more novelty preference. There are low number of D1 and D2 dopamine receptors in the prefrontal cortex until young adulthood as compared to the striatum and nucleus accumbens where peak density of these receptors is found in adolescence.
midbrain
Parents on average become concerned regarding the delayed or abnormal development of a child subsequently diagnosed with autism spectrum disorder at ___ months of age. Note that this is 19 months from average age of diagnosis, which occurs approximately at 3 years of age.
17
One of the significant limitations of direct observation is that it only represents a small sample of the child’s developmental skills, and the clinician might ___ important but infrequent behaviors.
miss
Self-___ is characterized by the ability to effectively manage one’s own thoughts, behaviors, and emotions, setting up practical goals and working towards achieving them, taking initiative, stress management, and incorporating discipline and motivating energies into life.
management
Self-___ is characterized by the ability to understand one’s emotions and behaviors and linking them to personal growth by identifying self strengths and limitations.
awareness
Bulimia nervosa is characterized by the presence of binge eating associated with recurrent use means to avoid gaining weight with the frequency of ___ a week for 3 months. The patient evaluates themselves based on their physical appearance. Cognitive-behavioral therapy is considered the first-line treatment choice for patients with bulimia nervosa as it is associated with a significant decrease in the behaviors of binge eating and compensatory behaviors. Fluoxetine is approved by the FDA for the treatment of bulimia nervosa.
once
The diagnosis of premenstrual dysphoric disorder is considered provisional until confirmed by prospective daily ratings during at least how many symptomatic cycles?
Two
For the patient suffering from encopresis, ___ periods of toilet sitting after a meal to capitalize on the gastrocolic reflex is encouraged rather than longer periods.
short
If mothers have history of unresolved trauma/mental illness history their infants are at higher risk of developing behavior problems and disorganized behavior. Meta-analysis has demonstrated that brief, age-appropriate, carefully tailored, and individualized interventions using ___-aided interventions can improve sensitive responding and other attachment-related parental behaviors. The psychologist then uses these videos to sensitize patients to infant communications and increasing patient enjoyment with their children. There is also modest improvement in the behavior of the children. This program may also be used to improve feeding patterns in mothers with eating disorders.
video
Supportive-expressive therapy is used to treat or prevent complicated ___ reactions in children.
grief
Angelman syndrome is characterized by intellectual and developmental delay, sleep disturbance, seizures, jerky movements (especially hand-flapping), frequent laughter or smiling, and usually a happy demeanor. Angelman syndrome is caused by ___ genes on chromosome 15 being deleted or inactivated.
maternal
Prader-Willi is a rare genetic disorder in which seven genes on chromosome 15 (q 11-13) are deleted or unexpressed on the ___ chromosome. Characteristics are low muscle tone, short stature, incomplete sexual development, cognitive disabilities, problem behaviors, and a chronic feeling of hunger that can lead to excessive eating and life-threatening obesity.
paternal
Vomiting starting ___ chemotherapy points to the diagnosis of anticipatory nausea and vomiting (AVN). Benzodiazepines are the drugs of choice. It is a conditioned symptom and does not respond well to conventional antiemetics. Patients respond well to benzodiazepines as well as cognitive-behavioral therapy (CBT). Since cognitive-behavioral therapy will take time to show its effect and she needs to have her chemotherapy session on time, this patient will benefit from benzodiazepines.
before
Decreased gray matter in bilateral ___-hippocampus complex and bilateral percuneus and slight increase in volume in middle-inferior frontal gyrus have been implicated in defective social communication found in autistic children.
amygdala
To establish the diagnosis of panic disorder, at least one of the attacks must be followed by ___ month (or more) of persistent concern or worry about additional attacks and/or a maladaptive change in behavior related to the attacks.
1
___ abnormalities are found in intermittent explosive disorder, particularly in the anterior cingulate and orbitofrontal complex.
Serotonergic
Tuberous sclerosis is a genetic disease inherited as an autosomal dominant condition. If one parent has this abnormal gene, then there is a ___ chance of future children having the disease.
50%
Type I error occurs when the null hypothesis (of no difference) is ___ when it should have been accepted, “false positive”. This means erroneously concluding that there is a difference between 2 groups when in fact there is no true difference between groups.
rejected
Disinhibited social engagement disorder (DSED). DSED is an attachment disorder that is characterized by a pattern of behavior involving culturally inappropriate and excessively familiar behavior with relative strangers. Serious social neglect is one of the criteria required to establish the diagnosis of DSED. Conditions of social neglect are usually present during the first few months of life. There is no evidence that social neglect starting after the age of ___ years is associated with the manifestation of this disorder.
2
Children’s attributions or explanations for actions and their results affect self-esteem enormously. “Mastery-oriented attributions” give credit for success to innate ability and explain failure by what is controllable (the need to study harder) or not fundamental (the test was especially tough). Children who attribute failure to a lack of ability may be working from “___ helplessness” and are at risk for “giving up.”
learned
Goiter can be an anomaly of concern in the fetus exposed to lithium in the ___ trimester of pregnancy.
later
At ~11yo, as opposed to preschool-age children, hallucinations are not likely to be transient or benign, and in the absence of trauma can ___ severe mental illness later in life.
predict
At ___ month, the child should be able to lift the chin, have a tight grasp, follow to the midline, make sounds other than crying, and be startled by sounds.
one
At ___ months of age, the child should be able to roll on the side, reach for the parent’s face, visually follow a person who is moving across the room, and vocalize when spoken to.
3
At ___ months old child should be able to sit propped on hands, roll over, demonstrate beginning stranger anxiety (recognize familiar versus unfamiliar people), smile/vocalize to mirror and transfer objects from hand to hand.
6
The child should be able to crawl with all 4 limbs, pull to a stand, use pincer grip, wave, and say mama/dada at ___ months. The child should also demonstrate more fully developed stranger anxiety at 9 months.
9
The child walks, uses a mature fine pincer grasp, follows the one-step command with a gesture, imitates others, and says mama/dada discriminately at ___ months.
12
The child creeps upstairs, scribbles, builds a two-block tower, and use 4-6 words at ___ months of age.
15
Polymorphisms in contactin-associated protein-like 2-gene (CNTNAP2) have been detected in ___ mutism and in social anxiety symptoms and traits. There seems to be a strong heritability in selective mutism with parents or siblings exhibiting either selective mutism or social anxiety traits.
selective
Dysfunctional ___-emotion processing found in disruptive mood dysregulation disorder has been attributed to a disturbed amygdala-prefrontal cortex circuitry.
face
Bipolar disorder is characterized by alternating episodes of mania and depression. This switch has its own mechanism of action. Catecholaminergic disruption is associated with episodes of mania whereas cholinergic dysfunction is associated with episodes of ___.
depression
Long alleles of the MAOA-uVNTR promoter polymorphism have been associated with ___disorder with agoraphobia.
panic
Schizophrenia has been attributed to a disturbed cellular balance between excitation and inhibition. This disturbance has been associated with altered function of the ___ receptor.
NMDA