HY 3/ Flashcards
Selective mutism is most commonly a manifestation of ___ anxiety in children.
social
___ agreement is an interest-based method used to resolve any conflicts between 2 people.
Integrative
The ___ (PPVT) specifically assesses verbal comprehension (understanding) in children with expressive impairments. In the test, 175 picture plates with 4 pictures on each plate are shown to the subject. The subject points to picture most like the stimulus word (shown on a card). Note that the PPVT tests comprehension in verbally handicapped subjects who need not respond verbally. Subjects point to the correct answer.
Note that there is another test with the word “Peabody,” the Peabody Individual Achievement Test.
Peabody Picture Vocabulary Test
The Woodcock-Johnson and the (Wechsler Individual Achievement Test) WIAT-II are achievement tests; that is, they can identify specific skill deficits that can become the focus of ___ intervention.
educational
The hallmark behavioral profile of ___ is hyperphagia, food-seeking behavior, non-food-related obsessive-compulsive rituals, self-mutilations, temper tantrums, and intellectual disability. Such children are usually obese because of hyperphagia and have other comorbid psychiatric issues like depression stemming from low self-esteem and bullying from peers. The genetic mutation associated with this syndrome lacks expression on paternal chromosome 15; it can be due to 3 causes: paternal deletion, maternal uniparental disomy (UPD) imprinting defect.
Prader-Willi syndrome
___ according to cognitive testing done in children with intellectual disabilities having concurrent disruptive behavior, has shown to improve the cognitive ability along with good control over behavioral issues. The improvement is small but significant according to the clinical findings.
Risperidone
___ 94-142 is also known as the Education of All Handicapped Children Act (or EHC). This act required all public schools accepting federal funds to provide equal access to education for children with physical and mental disabilities. Public schools were required to evaluate handicapped students and create an educational plan with parent input that would emulate as closely as possible the educational experience of non-disabled students. EHC was revised and renamed the Individuals with Disabilities Education Act (IDEA) in the 1990s.
Public Law
Children acquire the capacity for a mature understanding of death as irreversible, final (associated with non-functionality), and inevitable or universal between the ages of ___ and 7 years.
5
Neuroleptic malignant syndrome is evident by rigidity, hyperthermia, and altered sensorium after starting haloperidol or other antipsychotic. It is a rare side effect of antipsychotics. Management includes hydration, stopping the offending drug, and /or ___ and dantrolene. Special attention should be paid to renal function tests as these patients may develop rhabdomyolysis. Bromocriptine acts by increasing dopamine and overcoming the neuroleptic-induced dopaminergic blockade.
bromocriptine
ADHD occurs about 10-fold more often than expected with ODD and ___, while major depression is 7-fold more common and substance use disorder 4-fold more common (the latter in adolescents).
Conduct disorder
Williams syndrome is a rare neurodevelopmental disorder caused by a deletion of about 26 genes from an arm of chromosome ___; the syndrome is characterized by “elfin” facial features, cardiovascular problems, and developmental delay coupled with strong language skills.
7
A recent study of a cohort of children born in the US in 2001 found that 13% of them had a developmental delay. Of these children with developmental delay, only ___ at 2 years of age were receiving the early intervention services mandated by IDEA.
10%
The child’s hospital bed is a designated safe place. In contrast, all painful procedures need to be carried out in the ___ room.
treatment
Elevated whole blood ___ is the first biomarker identified in autism spectrum disorder (ASD) and is present in more than 25% of affected children.
serotonin
During a pre-transplantation psychiatric evaluation of an adolescent patient it is beneficial to meet the ___ first to reassure the adolescent that his concerns and feelings hold primary importance.
patient
The kappa statistic is employed in assessing level of agreement across ___. Values above .75 represent high levels of agreement, values in the range of .40 to .75 represent moderate levels of agreement, and values below .40 represent low levels of agreement.
raters
A p value is the statistical ___ of a result.
significance
Hypopigmented macules (ash-leaf spots) and shagreen patches are associated with ___, an autosomal dominant neurocutaneous syndrome associated with intellectual disability & epilepsy.
tuberous sclerosis
Hand wringing (the clasping together and squeezing of one’s hands) and choreatic movements are characteristic of ___ syndrome (RS), a neurodevelopmental disorder caused by a mutation in MECP2 in the region of the gene methyl CpG-binding protein. Early neurological regression and a delay in acquiring new skills is another important clinical presentation or RS. Children with RS typically have regression of milestones, hand-wringing movement, and abnormal gait.
Rett
ASD has been associated with acceleration of ___ growth due to failure of apoptosis in the cortex.
head
Several second-generation antipsychotics (SGAs) have been approved by the United States Food and Drug Administration (FDA) for the management of acute and/or mixed ___ in children and adolescents who are 10-17 years of age. These include risperidone, olanzapine, asenapine, aripiprazole, and quetiapine.
mania
Lithium has been approved by the FDA for the treatment and prevention of recurrence of BPAD mania & maintenance in those aged ___ years and older.
7
A combination of fluoxetine and olanzapine is FDA approved for the treatment of bipolar ___ in 10-17-year-old patients.
depression
(Olanzapine by itself has FDA approval, 13-17, for schizophrenia and Mania (bipolar acute mania)
A 2-year-old should have a vocabulary of ___ words and be able to combine them into 2-word phrases. Children at this age start learning pronouns, although they frequently use me instead of I. The child should be able to follow multi-step commands. Two-years-old can also run, throw a ball overhand, and kick a ball. They should be able to copy a straight line when drawing and turn pages in a book.
50
Tourette’s syndrome (TS), which is characterized by the presence of multiple motor tics and vocal tics with the onset before 18 years of age. The tics appear several times a day nearly every day for more than one year with a remission period of not more than ___ months.
2
___ (HRT) is the first-line treatment choice in patients with TS, which has shown effectiveness in reducing the severity of tics. Pharmacological treatment is usually withheld until the tics are causing significant impairment of functioning due to their significant adverse effects. Clonidine is an alpha 2 receptor agonist which is preferred first-line treatment option when considering pharmacotherapy even though it is less effective than haloperidol because of its favorable adverse effects profile when compared to haloperidol.
Habit reversal training
Cross-sectional study analyzes subjects and identifies the risk factors, exposure, and case status at a single point in time. The outcome in both groups with and without exposure can then be compared. A cross-sectional study is for health behaviors and exposure and is beneficial for descriptive epidemiology. In this study, the researcher wants to identify psychiatric disorders in children and adolescents in a specific area. A cross sectional study is used for ___.
prevalence
In a Case-control study the subjects are identified and selected depending on whether they have the ___ or not. The exposures are then recognized by looking backward from records. It compares 2 groups retrospectively and is useful for studying rare diseases.
outcome
Becker muscular dystrophy (BMD) is an X-linked recessive muscular dystrophy that results in slowly progressing muscular weakness in the legs and pelvis. Compared to DMD, BMD symptoms occur later in life, often in the ___-teen years. Some functional dystrophin is present in BMD, which makes it less severe than DMD. Children with BMD do not have cognitive impairment or cardiomyopathy. Arrhythmias occur, but less frequently in BMD than in DMD.
pre
Duchenne muscular dystrophy (DMD) is X-linked recessive with an ___ of dystrophin and starts in childhood around 2 to 6 years of age. A range of 20% to 50% of children has cognitive impairment and intellectual disability. Survival is rare beyond the early 30s.
absence
Friedreich’s ataxia is caused by expansion of ___ and results in cerebellar degeneration and gait disturbance. The peak onset is between 10 and 13 years of age and also results in hearing loss, dysarthria, and cognitive deficits.
GAA
Guillain-Barre syndrome is a post-infectious inflammatory neuropathy and results in ___ in the extremities. It results in difficulty walking and ataxia, and weakness “spreads upwards.”
paresthesias
Myotonic dystrophy is the most common type of muscular dystrophy that occurs in ___, but it can occur in childhood as well. It also has other effects such as causing cataracts, conduction issues in the heart, and intellectual disability.
adulthood
Major depressive disorder with anxious distress can be mild (two symptoms), moderate (___ symptoms), severe (four or more), depending on number of features like feeling tense, difficulty concentrating due to worry, fear something awful may happen.
three
Among adolescents and young adults, a history of
___ depression is predictive of a future hypomanic episode. ___ depression is marked by mood reactivity, hyperphagia, hypersomnia, leaden paralysis, and interpersonal rejection sensitivity.
atypical
Individuals with moderate intellectual disability, as with someone with an IQ of 45, can often achieve ___ when living in a supervised environment such as a group home.
success
The cognitive ___ experienced by many patients with Down syndrome in their 30s and older may make maintenance at home impossible.
decline
Once children and adolescents have been identified to be at increased risk of schizophrenia, the goal would be to prevent or slow the onset of the illness. The Australian group found an association of cognitive-behavioral therapy and ___ with delayed progression of psychotic symptoms.
risperidone
MECP2 gene mutation occurs in patients with Rett syndrome. This gene is associated with the production of a protein MeCP2, which is essential for brain development. Rett syndrome occurs mostly in ___ (MeCP2 is in X chromosome, so girls have greater chance of mutation), who lose their milestones after achieving them, and a characteristic repetitive hand wringing or tapping movement.
girls
HGPRT gene mutations cause ___. It is a rare disorder occurring almost exclusively in males and is characterized by the enzyme hypoxanthine-guanine phosphoribosyltransferase deficiency. The patient has behavioral and neurological abnormalities due to the overproduction of uric acid. They present with bladder and kidney stones, cognitive disabilities, and arthritis. Patients with Lesch Nyhan have self mutilating behaviors; this syndrome is inherited as an X linked recessive genetic disorder.
Lesch Nyhan syndrome