human transport !! Flashcards
pulmonary circulation !
transports blood between the heart and the lungs
- pulmonary ateries : heart -> lungs
- pulmonary veins : lungs -> heart
systemic circulation !
transports blood between the heart and the other parts of the body
oxygenated blood : left side of heart -> arteries -> rest of the body
deoxygenated blood : rest of body -> veins -> right side of heart
advantages of double circulation !
blood enters pulmonary circulation (lungs) at a lower pressure than blood leaving the heart
- ensures that blood flows slowly through the lungs -> allowing sufficient time for blood to be fully oxygenated before returning to heart
blood is pumped into the systemic circulation (rest of the body) at high pressure
- allows for oxygenated blood to be distributed to body tissues more quickly -> maintain high metabolic rate in mammals
chambers of heart !
atria : thinner walls compared to ventricles
- force blood into ventricles : short distance -> lesser pressure needed
left ventricle thickest : pumps blood to rest of the body
- longer distance -> more pressure needed
right ventricle less thicker : ensures that rate of blood flow is lower
- sufficient time for gaseous exchange to take place in the lungs
medium septum !
muscular wall dividing left and right sides of heart
- ensure oxygenated and deoxygenated blood to mix -> ensures there’s efficient transport of oxygen
movement of blood !
rest of the body -> vena cava -> right atrium -> tricuspid valve -> right ventricle -> semilunar valve -> pulmonary arch -> pulmonary artery -> lungs -> pulmonary vein -> left atrium -> bicuspid valve -> left ventricle -> semilunar valve -> aortic arch -> aorta -> rest of the body
ventricular systole !
ventricles : contract
atria : relax
- increase in ventricular pressure causes tricuspid + bicuspid valve to close -> lub
ventricular diastole !
ventricles : relax
- decrease ventricular pressure -> closure of semilunar valves -> dub sound
atery !
carries blood away from heart
small lumen + thick elastic muscular walls to withstand the high pressure exerted by heart
vein !
carries blood towards the heart
large lumen + thinner elastic muscular walls : carry blood at lower pressures
contains semilunar valves to prevent backflow of blood with lower pressure
capillary !
allows exchange of gases, nutrients + waste materials between the blood & cells
one cell thick -> shorter diffusion distance -> allow faster rate of diffusion
blood !
55% - plasma
45% - WBC, RBC, platelets
plasma !
90% - water
hormones : insulin
soluble proteins : fibrinogen, prothrombin, albumin, globulin, antibodies
food substances : glucose, amino acids, fats, vitamins
excretory products : urea, uric acid, creatinine, bicarbonate ions (CO2)
dissolved mineral salts : hydrogencarbonates, chlorides, sulfates, phosphates of Ca K NA
RBC / erythrocytes
produced in bone marrow, destroyed in spleen
limited life span of 120 days (3-4 months) -> due to lack of nucleus which is responsible for reproduction
RBC features/adaptations
- contains haemoglobin : combines reversibly with oxygen to form oxyhaemoglobin
- enabling RBC to transport O2 from lungs to all parts of body - circular, flattened biconcave shape : increases surface area to volume ratio
- increasing rate of diffusion of O2 - absence of nucleus : have more space
- can contain more haemoglobin - elastic, can turn bell-shaped : allows RBC to squeeze through blood vessels
- efficient transport of O2 to all parts of body
WBC / lenocytes
produced in bone marrow, destroyed in spleen
limited lifespan of a few days : involved in fighting against bacteria & viruses
- phacocytes
- lymphocytes
phagocytes
- engulf and destroy foreign particles by phagocytosis
lobed nucleus
granular cytoplasm
lymphocytes
produce antibodies to destroy foreign particles causing them to agglutinate -> easier for phagocytosis by phagocytes to take place
- easier to neutralise toxins produced by foreign particles
large rounded nucleus
small amt of non-granular cytoplasm
round in shape
limited movements
platelets / thrombocytes
formed from fragments of cells found in blood
- helps clots blood
blood groups !
plasma : contains natural antibodies which recognise and bind to antigens on RBC
agglutination / clumping of RBC : occurs when antibodies react with antigens on RBC
group A
antigen A
antibody b
group B
antigen B
antibody a
group O
universal donor
no antigen
antibodies a & b
group AB
universal acceptor
antigens A & B
no antibody
atherosclerosis !
condition whereby fatty substances build up in coronary arteries
- narrows lumen
effects of coronary heart disease !
heart attack : occurs when blood flow to a particular part of the heart is blocked
- lumen of atery becomes narrower as blood clot forms in atery -> reduced blood flow to heart -> heart muscle receives reduced O2 supply
- insufficient O2 and glucose
angina : chest pain
causes of coronary heart disease !
- diet high in saturated fats & cholesterol
- increases fatty deposits forming on the inner walls of the coronary arteries
2, smoking : contains nicotine & carbon monoxide
- nicotine : causes the release of adrenaline -> increases heart rate + blood pressure
- carbon monoxide : damages lining of inner walls of coronary arteries + increases the formation of fatty deposits on the inner walls + blood clots that get trapped within the damaged arteries
- stress : increases release of adrenaline
- increases heart rate + blood pressure - high blood pressure : damages lining of inner walls of coronary arteries + increases formation of fatty deposits and blood clots
preventive measures !
- healthy diet : low saturated fats + cholesterol
- avoid smoking
- manage stress
- exercise regularly
clotting of blood !
when blood vessels : damaged
- damaged tissues + blood platelets : release enzyme thrombokinase
prothrombin in plasma -> thrombin by thrombokinase, in presence of calcium ions
thrombin : catalysts concentration of soluble protein fibrinogen -> insoluble fibrin threads
- entangle blood cells to form a clot -> sealing the wound -> preventing entry of microorganisms & loss of more blood
phagocytosis !
phagocytes engulf & destroy foreign particles
dead cells combine with dead bacteria to form pus
antibodies !
bind to bacteria : ruptures bacterial surface membrane
- causes bacteria to bind together : agglutination -> can be easily engulfed by phagocytosis
neutralists harmful substances (toxins) produced by bacteria