Human Physiology Flashcards
Where do you gain and lose water?
water ingested- food and water, water formed in the metabolism
l- urine, feces excretion, evaporation, sweat and expired air
In water balance what is the only water control that is under homeostasis control?
Urinary secretion
What part of the renal filters plasma?
The glomerulus
What happens in the proximal convoluted tubule?
Ions, small organic molecules are reabsorbed
Secretion of H+ (acid-base balance)
Active transport; facilitated diffusion
Relatively little control over what is reabsorbed
What opposes the capillary hydrostatic blood pressure?
plasma protein oncotic pressure
what is the hoop of henle important for?
concentration of urine
The length of the henle hoop corrolates to what?
concentration of urine
What does the distal convoluted tubule do?
reabsorption of Na, cl and ca
secretion of H, K
what hormones control the activity of the distal convoluted tubule?
Aldosterone
Atrial natriuretic hormone
ADH (in most distal parts)
Parathyroid hormone
What are the collecting ducts responsible for?
Water reabsorption, under the influence of ADH
ADH membrane channels for water reabsorption
What are 3 compounds responsible for the regulation of water?
Antidiuretic Hormone (ADH)
Renin-angiotensin-aldosterone
Atrial Natriuretic Hormone (ANH)
also: called ANF, ANP
Where is ADH produced?
hypothalamus, released from posterior pituitary gland
What increases ADH secretion?
ECF volume (low pressure receptors in atria and great veins)
ECF osmolarity (Osmoreceptors in hypothalamus)
ADH also causes constriction of blood vessels (vaso-press-in)
What control are electrolytes subject too?
homeostatic control
What does Renin-angiotensin-aldosterone system do?
Promotes reabsorption of Na+ (and water) in DCT; exchange for K+, H+
Angiotensin is a potent vasoconstrictor
What affect does Atrial Natriuretic Hormone have on Na+
increases excretion
What hormone is K+ regulated by?
aldosterone
What are disorders associated with ADH secretion?
Hypo-secretion:
Diabetes insipidus
Large volumes of insipid (tasteless) urine (cf. diabetes mellitus)
Hyper-secretion:
Syndrome of inappropriate ADH (SIADH)
Excess ADH water retention
describe the effects of K+ on nerve function?
Increasing ECF [K+] depolarisation
Depolarisation causes axons to fire AP
But the MP does not return to ‘resting’ levels
Result is that axon remains in an extended ‘refractory period’
Describe what happens to blood during shock
The decreased blood volume results in a fall in blood pressure and impaired delivery of nutrients to cells
What are four reactions to blood loss?
Immediate:
Stop the bleeding
Short term:
Restore blood pressure
Medium term:
Restore fluid volume
Long term:
Replace blood constituents
Describe immediate blood loss
Stopping blood loss (haemostasis)
Several components involved:
Vascular response
Platelet response
Plasma response (Coagulation)
In blood loss what is the vascular response in regards to smooth muscle?
Spasm due to trauma
Myogenic response
Humoral factors (vasoconstrictors)
in blood loss what is the vascular response in regards to epithelium?
Platelet adhesion and aggregation
Anticlotting and fibrinolysis
Describe the platelet response to blood loss?
Damage to blood vessel turbulent blood flow platelets come into contact with vessel wall (collagen)
Platelets adhere; clump together (aggregate)
Release chemicals that cause further aggregation (Positive feedback)
Formation of platelet plug
Effective in sealing small blood vessels
What does a platelet plug do?
effective in sealing small blood vessels
What is coagulation?
Various plasma proteins and tissue components combine to convert fibrinogen fibrin to form the blood clot
Where are most clotting factors produced?
the liver
What is required for the synthesis of clotting factors
vitamin K