human disease Flashcards

1
Q

Which of the following statements regarding the resuscitation council’s recommendations of the ratio of compressions to breaths is correct?

a. 15:2 if there is 1 rescuer
b. 15:2 if there are 2 rescuers
c. 30:2 if there is 1 rescuer
d. 5:1 if there are 2 rescuers
e. aim is 200 compressions per min

A

C - 30:2

  • aim for 100 compressions per minute
  • the same regardless of the number of rescuers
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2
Q

A patient complains of severe chest pain whilst in the dental chair.
Which of the following is regarded as appropriate management?

a. administer glucose tablets only
b. lie the pt flat
c. lie the pt in the recovery position
d. administer IV GTN
e. give the pt oxygen

A

E - administer oxygen

Sublingual GTN would be the correct route of administration.

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3
Q

Which of the following statements regarding Down’s Syndrome is INCORRECT?

a. caused by trisomy 21
b. incidence increases with the age of the mother
c. pts suffer from microglossia
d. pts suffer from cardiac anomalies
e. pts have delayed eruption of their dentition

A

C - pts have microglossia

Down’s pts have MACROglossia.

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4
Q

A 35 year old pt has a productive cough with weight loss and drenching night sweats. A chest x-ray shows a right hilar mass with partial collapse of the upper lobe.

What is the likely diagnosis?

a. pulmonary embolus
b. pneumonia
c. TB
d. smoker’s cough
e. asthma

A

C - tuberculosis

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5
Q

A 45 year old alcoholic male is admitted with confusion, ataxia and opthalmoplegia. He is thin and wasted.

Which vitamin deficiency does he have?

a. vitamin A
b. vitamin B1 (thiamine)
c. vitamin B12
d. vitamin D
e. vitamin k

A

B - vitamin B1 deficiency

This pt has Wernicke’s encephalopathy (acute confusion, nystagmus, ataxia, variable opthalmoplegia) caused by thiamine deficiency.
If left untreated, will lead to irreversible neurological damage.

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6
Q

Which of the following statements regarding bacterial endocarditis is correct?

a. does not affect prosthetic heart valves
b. does not occur whilst using CPITN probe
c. in the uk, it is usually caused by strep viridans
d. usually responds well to a 2 week course of amoxicillin

A

C - usually caused by strep viridans

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7
Q

Which of the following statements regarding AF is correct?

a. uncommon in elderly people
b. treated with digoxin
c. does not cause fainting in elderly people
d. their is a p wave on an ECG
e. the thromboembolic risk is reduced by aspirin more than warfarin

A

B - treated by digoxin

  • common in elderly people
  • diagnosed on an ECG due to the LACK of p wave
  • causes fainting in elderly people
  • treated with digoxin
  • warfarin is more efficacious than aspirin in reducing thromboembolic risk
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8
Q

Sudden onset of breath is not associated with which of the following:

a. asthma
b. emphysema
c. pulmonary embolism
d. pneumothorax
e. foreign body inhalation

A

B - emphysema

Emphysema is a chronic disease leading to a decrease in lung function over a period of time so therefore not presenting with acute shortness of breath.

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9
Q

Which of the following statements regarding jaundice is correct?

a. always accompanied by dark stools and dark urine
b. only caused by viral infections
c. associated with pain and weight gain in carcinoma of the pancreas
d. causes the alanine aminotransferase and alkaline phosphate levels to be reduced
e. can be acclaimed with post-XLA haemorrhage

A

E - acclaimed with post-xla haemorrhage

  • can also be caused by bacterial as well as viral infections
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10
Q

Dysphasia is associated with which one of the following conditions?

a. lobular pneumonia
b. oesophageal carcinoma
c. hyperthyroidism
d. hypothyroidism
e. atrial fibrillation

A

B - oesophageal carcinoma

Oesophageal carcinoma causes progressive dysphagia and this can have a rapid onset.

(dysphagia = swallowing difficulty)

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11
Q

A pt with uncontrolled thyrotoxicosis is UNLIKELY to have:

a. increased sweating
b. heart block
c. resting tremor
d. lid retraction
e. diarrhoea

A

B - heart block

Thyrotoxicosis is likely to cause AF and increased chronotropic rate rather than heart block.

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12
Q

Weight gain is a feature of:

a. over treatment with steroids
b. carcinoma of the stomach
c. inflammatory bowel disease
d. thyrotoxicosis
e. chemotherapy

A

A - over treatment with steroids

(pts are also at risk of osteoporosis, diabetes and immunosuppression)

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13
Q

Pts on dialysis treatment are at risk of:

a. infections
b. malnutrition
c. bleeding diathesis
d. all of the above
e. none of the above

A

D - all of the above

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14
Q

Which of the following conditions are transplant pts NOT at risk of?

a. opportunistic infections
b. cancer
c. lymphomas
d. peptic ulcers
e. osteoporosis

A

D - peptic ulcers

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15
Q

One of the physical signs of a left lower motor neurone lesion of the 7th cranial nerve is:

a. sparing of the muscles of the forehead on the same side
b. inability to close the right eye
c. loss of power in the left muscles of mastication
d. hyperacusis if the nerve to stapedius is involved
e. decreased sensation over the left maxilla and mandible

A

D - hypercausis if the nerve to stapedius is involved

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16
Q

Which of the following regarding trigeminal neuralgia is correct?

a. pain is continuous
b. pain involves more than 1 branch of trigeminal nerve
c. there is a precise trigger point
d. dental XLA may help
e. drug of choice is a steroid

A

C - there is a precise trigger point

Trigeminal neuralgia is characterised by an electric shock-like shooting pain which involves 1 branch of the trigeminal nerve.
There is a trigger point or movement which precipitates the pain (e.g: cold wind, shaving)

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17
Q

Which of the statements regarding warfarin is true?

a. warfarin treatment for a pulmonary embolus can be interrupted safely for 1 week when dental tx is required
b. warfarin causes reduction of clotting factors II, VII, IX and X
c. its effects can be revered by protamine sulphate
d. bleeding time is the monitoring test for warfarin
e. it has a short life

A

B - warfarin causes reduction of clotting factors II, VII, IX and X.

  • has a long half life (48-72 hrs)
  • metabolised in the liver and monitored using INR
  • reversal agent is vitamin K
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18
Q

Which of the following is not used in the treatment of anaphylaxis?

a. intramuscular adrenaline injection
b. intramuscular chlorphenamine injection
c. hydrocortisone IV injection
d. IV diazepam
e. oxygen

A

D - IV diazepam

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19
Q

Which of the following would NOT raise suspicion of physical abuse in a child?

a. skull fracture in a 6 week old baby who allegedly rolled off the bed
b. torn lingual fraenum in a 2 year old child
c. bruises of various ages over the shins of a 6 year old
d. bruises of various ages over the back and buttocks of an 8 year old
e. report by an 8 year old sibling of an excessive beating

A

C - bruising on shins of a 6 year old

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20
Q

Which of the following regarding chickenpox is INCORRECT?

a. may be contracted by contact with fluid from vesicles
b. infectious for 7 days after all vesicles have crusted over
c. potentially life threatening in children receiving cancer chemotherapy
d. encephalitis is generally benign and in most cases resolves completely
e. recognised cause of congenital malformation when the mother is affected in the first 5 months of pregnancy

A

B - infectious for 7 days after all vesicles have crusted over

The virus is spread by respiratory tract droplets or by contact with fluid from the vesicles - not infectious once the vesicles have dried out.

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21
Q

Which of the following regarding HIV in children is FALSE?

a. due to the administration of contaminated blood products
b. may present with pneumocystis pneumoniae
c. may present with neurological signs in the absence of immunodeficiency
d. more likely to present with recurrent bacterial infections than in adults
e. may be acquired by breastfeeding from an infected mother

A

A - mainly occurs due to the administration of contaminated blood products

Most HIV in children occurs from vertical transmission from an infected mother.

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22
Q

In the tx of asthma:

a. most children over 6 can use a metered dose aerosol effectively without a spacer
b. use of a regular inhaled steroid is limited by a high incidence of side effects
c. advice should be given to restrict the child’s participation in sports
d. oral corticosteroids should be reserved only for children who require hospital admission
e. regular anti-inflammatory treatment should be recommended for a child who requires a bronchodilator most days

A

E - regular anti-inflammatory treatment should be recommended for a child who requires a bronchodilator most days.

Frequent bronchodilator use suggests chronic asthma for which anti-inflammatory treatment would be appropriate.

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23
Q

A 46 year old woman presents with spider naevi, bruising, confusion and jaundice.

What would be the most appropriate diagnosis?

a. alcoholic liver disease
b. congestive heart failure
c. haemochromatosis
d. hepatitis B
e. metastatic liver disease

A

A - alcoholic liver disease

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24
Q

A 27 year old IV drug user presents with fever and abdominal pain.

What would be the most appropriate diagnosis?

a. alcoholic liver disease
b. congestive heart failure
c. haemochromatosis
d. hepatitis B
e. metastatic liver disease

A

D - hepatitis B

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25
Q

A 50 year old woman presents with pigmented skin, type 1 diabetes and raised transaminases.

What would be the most appropriate diagnosis?

a. alcoholic liver disease
b. congestive heart failure
c. haemochromatosis
d. hepatitis B
e. metastatic liver disease

A

C - haemochromatosis

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26
Q

A 50 year old woman presents with jaundice 3 years after chemotherapy for breast cancer.

What would be the most appropriate diagnosis?

a. alcoholic liver disease
b. congestive heart failure
c. haemochromatosis
d. hepatitis B
e. metastatic liver disease

A

E - metastatic liver disease

(cancer starting in one part of the body and spreads to the liver)

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27
Q

A 75 year old man presents with shortness of breath, raised jugular venous pressure and swollen legs.

What would be the most appropriate diagnosis?

a. alcoholic liver disease
b. congestive heart failure
c. haemochromatosis
d. hepatitis B
e. metastatic liver disease

A

B - congestive heart failure

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28
Q

Following oral administration of a 3g sachet of amoxicillin, a 20 year idk woman reports shortness of breath and the development of a red rash on her body.

What would the most appropriate management option be for this scenario?

a. adrenaline 1:1000 (1mg/ml)
b. adrenaline 1:10000 (1mg/10ml)

A

A

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29
Q

A 20 year old man in the waiting room is shaking involuntarily, frothing at the mouth and showing signs of incontinence.

What would the most appropriate management option be for this scenario?

A

Diazepam

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30
Q

A 57 year old woman with type 1 diabetes collapses in the dental chair and a dipstick shows low blood glucose.

What would the most appropriate management option be for this scenario?

A

Glucagon

(counteracts the actions of insulin top increase blood sugar levels)

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31
Q

Whilst being treated, a 60 year old man complains of severe central crushing chest pains which radiate down the left arm. The pain does not respond to GTN spray or oxygen.

What would the most appropriate management option be for this scenario?

A

Aspirin

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32
Q

Which of the following might make a pt more susceptible to infective endocarditis following dental tx?

a. previous history of rheumatic fever
b. presence of a pacemaker
c. congenital cardiac lesion
d. diagnosis of AF
e. heart murmur

A

A, C and E - history of rheumatic fever, congenital cardiac lesion and heart murmur

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33
Q

A pt tells you they have had hepatitis. Which of the following may be of concern when providing dental tx for them?

a. the pt will need AB cover for invasive procedures
b. increased bleeding following invasive procedures due to impaired synthesis of clotting factors
c. high risk of infective endocarditis after XLA
d. possible cross infection risk
e. impaired drug metabolism

A

B, D and E - increased bleeding following invasive procedures, cross infection risk and impaired drug metabolism.

(pts with liver disease are likely to have impaired clotting and drug metabolism)

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34
Q

Which of the following about Down’s Syndrome are true?

a. caused by trisomy 20
b. caused by trisomy 21
c. incidence increases with increasing age of the mother
d. often causes delayed teeth eruption
e. pts often have microglossia
f. pts often have congenital cardiac defects

A

B, C, D and F - trisomy 21, increase incidence with age, delayed tooth eruption, congenital cardiac defects.

(causes MACROglossia)

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35
Q

A pt complains of severe chest pain whilst in the dental chair. Appropriate management includes:

a. lie pt flat
b. lie pt in the recovery position
c. administer sublingual GTN
d. give oxygen
e. administer Hypostop gel buccally

A

C and D - administer sublingual GTN and oxygen

36
Q

Anaphylaxis:

a. is caused by an acute-type IV allergic response
b. results in acute hypertension, bronchospasm and uticaria
c. managed by lying the pt flat and maintaining the airway
d. is managed by giving 0.5ml of 1:1000 adrenaline IV
e. managed by giving oxygen

A

C and E - lie pt flat and give oxygen

(anaphylaxis is caused by a type 1 hypersensitivity reaction where histamine is released from mast cells, causes hypotension, bronchospasm and uticaria and adrenaline is given intramuscularly)

37
Q

Pts with which of the following conditions/drug treatment regimens may be at risk for an addisonian crisis?

a. Addison’s Disease
b. diabetes insipidus
c. secondary hypoadrenalism
d. long-term steroid therapy
e. cushing’s syndrome

A

A, C and D - addison’s, secondary hypoadrenalism and long-term steroid therapy.

38
Q

Diabetic pts:

a. have reduced resistance to dental infection
b. have faster healing following surgery
c. may have accelerated periodontal disease
d. are more prone to dental cysts
e. should not be given lidocaine and adrenaline as LA

A

A and C - reduced resistance to infection and may have accelerated periodontal disease

39
Q

Which of the following measures are appropriate for managing a patient experiencing an addisonian crisis?

a. place the pt in a horizontal position
b. give glucagon
c. give IV hydrocortisone
d. set up IV infusion of fluid
e. call for medical assistance

A

C, D, E - IV hydrocortisone, IV infusion of fluid and call for medical assistance.

40
Q

Features of Paget’s Disease include:

a. hypercementosis of teeth which causes difficulties when extractions are needed
b. alveolar ridges may increase in size so that new dentures need to be made
c. radiographs of bone may show radiolucent areas along with sclerotic areas
d. patients may suffer from symptoms of compression of cranial nerves
e. development of osteosarcoma is a common consequence

A

A, B, C, D - hypercementosis, increased alveolar ridges, radiographs showing radiolucent and sclerotic areas, symptoms of cranial nerve compression.

(Paget’s is characterised by excessive osteoclastic bone resorption followed by disordered osteoblastic activity. Leads to excessive new weak and abnormal bone formation.)

41
Q

Pts with which of the following conditions may be on long-term anticoagulants?

a. atrial fibrillation
b. previous deep vein thrombosis
c. cardiac pacemakers
d. prosthetic heart valves
e. ventricular fibrillation

A

A, B, D - AF, DVT and prosthetic heart valves.

(ventricular fibrillation isn’t compatible with life, the pt would be dead)

42
Q

Fat soluble vitamins:

a. vitamin B1
b. vitamin A
c. vitamin C
d. vitamin E
e. vitamin D

A

B, D and E - vitamins A, E and D.

43
Q

Regarding vitamin deficiency:

a. vitamin A deficiency causes scurvy
b. vitamin c deficiency causes beri beri
c. vitamin D deficiency results in skeletal decalcification
d. vitamin D deficiency in children causes rickets
e. vitamin D deficiency in children causes delayed tooth eruption

A

C, D and E - vitamin D deficiency causes skeletal decalcification, rickets and delayed tooth eruption.

44
Q

Which of the following are causes of finger clubbing?

a. bacterial endocarditis
b. bronchial carcinoma
c. congenital cyanotic cardiac disease
d. angina
e. chronic pulmonary suppuration

A

A, B, C, E - bacterial endocarditis, bronchial carcinoma, congenital cyanotic cardiac disease and chronic pulmonary suppuration.

45
Q

Features of bacterial endocarditis:

a. boutonnières deformity (funny finger deformity)
b. night sweats
c. history of recent dental XLAs
d. splinter haemorrhages
e. finger clubbing

A

B, C, D and E- night sweats, history of XLA, splinter haemorrhages and finger clubbing.

46
Q

Which of the following are concerns in pts who have undergone a transplant?

a. reduced resistance to infection
b. xerostomia
c. caries
d. susceptibility to osteoradionecrosis following XLA
e. bleeding tendency

A

A and E - reduced resistance to infection and bleeding tendency.

47
Q

With respect to bleeding disorders:

a. the prothrombin time is normal in patients with haemophilia
b. the activated partial thromboplastin time is normal in haemophilia A
c. haemophilia A affects women more frequently than men
d. haemophilia A is due to factor IX deficiency
e. bleeding due to von Willebrand’s disease may be treated with desmopressin and factor VIII concentrate

A

A and E - prothrombin time is normal in pts with haemophilia and bleeding due to VWD is treated with demopressin and factor VIII concentrate.

(the activated partial thromboplastin time is increased in haemophilia A)

48
Q

Which of the following puts patients at a greater risk of DVT?

a. being overweight
b. being on the oral contraceptive pill
c. early mobilisation following surgery
d. trauma to a vessel wall
e. thrombophlebitis

A

A, B, D and E - overweight, oral contraceptive pill, thrombophlebitis and trauma to vessel wall.

(thrombophlebitis - inflammation of a vein)

49
Q

Regarding Thyroid Hormones:

a. increase the metabolism of the body
b. in Hashimoto’s disease there is autoimmune destruction of the thyroid gland
c. Grave’s disease is a type of hypothyroidism
d. patients who are hypothyroid often have lethargy, cold intolerance and dry hair
e. patients who are hyperthyroid often have breathlessness, palpitations, increased pulse rate and constipation

A

A. B and D - thyroid hormones increase the metabolism of the body, hashimoto’s disease is autoimmune destruction of the thyroid gland, pts who are hypothyroid have lethargy, cold intolerance and dry hair.

50
Q

Regarding malignant disease:

a. Hodgkin’s disease is a type of leukaemia
b. acute leukaemia is a common childhood malignancy
c. pts with leukaemia often have intra-oral bleeding
d. patients with multiple myeloma often suffer from bone lesions and pain
e. oral SCC usually treated with chemotherapy

A

B, C and D - acute leukaemia is a common childhood malignancy, pts often have intra-oral bleeding and pts with multiple myeloma often suffer from bone lesions and pain.

(Hodgkin’s disease is a type of lymphoma where the lymphatic tissue is affected)

51
Q

What is the mechanism of action of a Type I autoimmune reaction?

A

immediate reagenic

(e.g: anaphylaxis, allergic asthma, allergic rhinitis)

52
Q

What is the mechanism of action of a Type II autoimmune reaction?

A

antibody dependent

(e.g: transfusion reactions, myasthenia gravis)

53
Q

What is the mechanism of action of a Type III autoimmune reaction?

A

immune complex

(e.g: rheumatoid arthritis, systemic lupus erythematous)

54
Q

What is the mechanism of action of a Type IV autoimmune reaction?

A

cell mediated

(e.g: hashimoto’s, contact dermatitis, pemphigoid)

55
Q

What type of drug is Warfarin and what is its mechanism of action?

A

Anticoagulant, vitamin K antagonist.

56
Q

Which 3 of these drugs interacts with warfarin and what effect does this have?

  • fluconazole
  • penicillin
  • metronidazole
  • adrenaline
  • paracetamol
  • carbamazepine
A
  1. fluconazole - enhances the anticoagulant effect.
  2. metronidazole - enhances the anticoagulant effect.
  3. carbamazepine - reduces the anticoagulant effect.
57
Q

Which conditions would warfarin be prescribed for?

A
  • DVT
  • atrial fibrillation
  • prosthetic heart valve placement
  • pulmonary embolus
  • cerebrovascular accident
  • antiphospholipid syndrome (Hughes Syndrome)
58
Q

What causes HIV?

A

Infection caused by human immunodeficiency viruses (RNA retroviruses).

59
Q

How is HIV transmitted?

A
  • sexually
  • through blood and blood products
  • IV drug misuse
  • from mother to child
60
Q

What part of the immune response is impacted by HIV?

A

T Cell Mediated Immunity, in particular CD4+ lymphocytes

61
Q

Name some conditions commonly associated with HIV.

(mainly oral)

A
  • kaposi’s sarcoma
  • hairy leukoplakia
  • candida infections
  • periodontal disease
  • non-hodgkin lymphoma
  • ANUG
  • ulcers
62
Q

Which type of drug is used to treat HIV?

A
  1. neucleoside reverse transcriptase inhibitors and non-neucleoside reverse transcriptase inhibitors
  2. protease inhibitors
63
Q

What is the clinical relevance of liver disease?

A
  1. pts have extensive bleeding due to abnormal clotting factors
  2. inability to metabolise drugs normally
  3. potential that pts have contagious transmissible diseases
  4. delayed healing
  5. IV sedation may result in coma
64
Q

How is Hepatitis A transmitted?

A

oreo-faecal

65
Q

How is Hepatitis B transmitted?

A

sexual contact, sharing needles, mother to baby at birth

66
Q

Which type of vaccination is used to immunise healthcare professionals against hepatitis B

A

recombinant DNA hepatitis surface antigen (HbsAg)

67
Q

Which dental problems does anaemia predispose to?

A
  1. glossitis (inflammation of the tongue)
  2. RAS
  3. candidal infection angular chelitis
68
Q

Which 4 groups of analgesics could you prescribe to a patient experiencing dental pain?

A
  • aspirin
  • paracetamol
  • NSAIDs - ibuprofen
  • opioids - morphine, codeine, dihydrocodeine, codeine phosphate
69
Q

Which 2 side effects can NSAIDs cause?

A
  1. gastric ulcers
  2. asthma attack
70
Q

Which syndrome can be caused by aspirin use?

A

Reye’s Syndrome - swelling in the liver and brain.

71
Q

What are 5 consequences of opioid use?

A
  1. dependence
  2. respiratory depression
  3. nausea
  4. vomiting
  5. constipation
72
Q

What are the potential consequences of paracetamol use?

A
  • liver damage
  • rashes
  • blood disorders (thrombocytopenia, leukopenia)
73
Q

What are the contraindications for aspirin use?

A
  • asthma
  • bleeding disorders
  • gastric or duodenal ulceration
  • pregnancy
  • child under 12
  • aspirin allergy
74
Q

Besides analgesia, which other property does paracetamol have?

A

antipyretic (reduces fever)

75
Q

What is the best time to carry out an appointment with a pregnant patient and why?

A

During the SECOND TRIMESTER as this is the safest time to perform dental treatment.

(ideally delay all major work until after pregnancy)

76
Q

In the event of a dental abscess, which antibiotics would be safe to prescribe to a pregnant patient?

a. metronidazole
b. erythromycin
c. penicillin

A

B and C - erythromycin and penicillin.

77
Q

What is infective endocarditis?

A

Inflammation of the endocardium of the heart valves and around congenital defects of the heart from an infection.

78
Q

What is the difference between bacteraemia and septicaemia?

A

Bacteraemia - low levels of bacteria found in the blood stream, usually not of consequence.

Septicaemia - sepsis caused by high levels of organisms in the blood stream

79
Q

Features of Gardener’s Syndrome.

A
  • multiple osteomas
  • intestinal polyps
  • cysts
  • skin fibromas
80
Q

Can arthritis cause implant failure?

A

No

81
Q

What is the role of collagen in wound healing?

A

initial activator of platelets

82
Q

Which thyroid issue presents with Pekinese eyes?

A

hyperthyroidism

83
Q

Which is the most common form of dementia?

A

Alzheimer’s

84
Q

Which medication can help control the involuntary movements in a Parkinson’s pt?

A

midazolam

(think seizures)

85
Q

Which virus may you be more worried about during pregnancy?

A

rubella - increased risk of congenital rubella syndrome to the foetus

86
Q

What is the marker found via blood tests which identifies Chron’s Disease?

A

c reactive protein - think CHRONS