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2 - MODA > Human Aspects of Cardiovascular & Renal Pharmacology > Flashcards

Human Aspects of Cardiovascular & Renal Pharmacology Flashcards

1
Q

Labelatol

A

Alpha-1, beta-1/2-receptor antagonist (more so beta than alpha)

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2
Q

Sodium nitroprusside

A

Metabolised to NO used in hypertensive emergencies (hydrolyses to cyanide in solution)

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3
Q

Pindolol

A

Mild partial beta-receptor agonist

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4
Q

Amyl nitrate

A

Nitrovasodilator

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5
Q

Nicotinic acid

A

Inhibits liver triglyceride production & VLDL secretion when used in large doses

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6
Q

Ranolazine

A

Inhibits late phase sodium current in cardiac myocytes used in angina

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7
Q

Minoxidil

A

Potassium channel opener used as an antihypertensive

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8
Q

Glyceryl trinitrate

A

Nitrovasodilator used to treat angina, especially in acute attacks
Poorly absorbed from stomach so taken sublingually

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9
Q

Flecainide

A

Class IC antidysrhythmic used for treatment of patients with anomalous conducting pathways

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10
Q

Isosorbide dinitrate

A

Nitrovasodilator used to treat angina

Much be converted by liver to isosorbide mononitrate

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11
Q

Doxazosin

A

Alpha-1-receptor antagonist

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12
Q

Cholestyramine

A

Anion exchange resin which inhibits bile acid reuptake

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13
Q

Hydralazine

A

Arteriolar vasodilator, mechanism unknown

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14
Q

Trimetaphan

A 
Ganglionic blocker (the first antihypertensive agents) give IV for rapid effect
Block all ganglionic transmission and were quickly superseded
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15
Q

Moxonidine

A

I-1-receptor agonist used as an anti-hypertensive (fewer side effects than alpha-1-receptor agonists)

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16
Q

Alpha-methylnoradrenaline

A

False transmitter of NA, centrally acting antihypertensive

Produced from alpha-methyldopa

17
Q

Simvastatin

A

Statin: HMG-CoA reductase inhibitor used in ischaemic heart disease or ‘high risk’ groups

18
Q

Ivabradine

A

Acts on HCN channels, inhibiting the f-current

Used to treat angina (may be helpful in stable angina)

19
Q

Sirolimus

A

Immunosuppressant used in drug-eluting stents to prevent neointimal proliferation

20
Q

Phentolamine

A

Non-selective alpha-receptor antagonist

21
Q

Guanfacine

A

Alpha-2-receptor agonist - used to treat hypertension

22
Q

Rosiglitazone

A

PPAR-gamma agonist increasing LXR expression and thus ABCA1 expression
Currently used in type II diabetes

23
Q

Paclitaxel

A

Anti-cancer drug which interferes with microtubular growth used in drug-eluting stents to prevent neointimal proliferation

24
Q

Bisoprolol

A

Beta-1-receptor antagonist used as an antihypertensive

25
Q

Nicorandil

A

ATP-Potassium channel opener which can be used in angina to protect against ischaemic injury

26
Q

Clofibrate

A

Stimulate lipoprotein lipase: decrease VLDL (& LDL) levels

27
Q

Ezetimibe

A

Binds & blocks cholesterol transporter, inhibiting uptake in the intestine
Circulates enterohepatically so is delivered repeatedly

2 - MODA (8 decks)

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