Drug Interactions with Receptors & Ion Channels

Question 1

Diltiazem

Answer 1

Benzothiazepine - L-type calcium channel blocker

Question 2

Tyrphostins

Answer 2

Receptor tyrosine kinase inhibitors

Question 3

Batrachotoxin

Answer 3

Prevents inactivation of voltage-gated sodium channels

Question 4

Mibefradil

Answer 4

Benzimidazolyl tetraline - L/T-type calcium channel blocker

Question 5

Verapamil

Answer 5

Phenylalkylamine - L-type calcium channel blocker

Question 6

Prednisolone

Answer 6

Corticosteroid: Glucocorticoid receptor agonist

Question 7

Spironolactone

Answer 7

Aldosterone receptor antagonist

Question 8

Nifedipine

Answer 8

Dihydropyridine - L-type calcium channel blocker

Question 9

Bay K 8644

Answer 9

Calcium ‘agonist’ - activates L-type calcium channels

Question 10

Aluminium tetrafluoride ion

Answer 10

Persistent G-protein activation

Question 11

Pertussis toxin

Answer 11

Inactivation of Gi

Question 12

Benzocaine

Answer 12

Uncharged local anaesthetic

Question 13

Metformin

Answer 13

Biguanide - orally acting hypoglycaemic agent

Question 14

Minoxidil, Nicorandil

Answer 14

Potassium channel opener

Cromakalim, Diazoxide

Question 15

Norethisterone

Answer 15

Progesterone receptor agonist

Question 16

Ethinylestradiol

Answer 16

Oestrogen receptor agonist

Question 17

Tetrodotoxin

Answer 17

Block Na channels externally

Question 18

Lidocaine

Answer 18

Fast-in, fast-out local anaesthetic

Question 19

Quinidine

Answer 19

Slow-in, slow-out local anaesthetic

Question 20

Cholera toxin

Answer 20

Persistent activation of Gs

Question 21

Glibenclamide

Answer 21

Sulphonylurea - closes ATP-potassium channel: orally acting hypoglycaemic agent
(Tolbutamide)

Question 22

Tamoxifen

Answer 22

Oestrogen receptor antagonist