HTN Meds

Question 1

Anti-HTN Med Locations

Vasc Smooth Muscle

Answer 1

Hydralazine
Minoxidil
Nitroprusside
Diazoxide
CCB
Thiazides

Question 2

Anti-HTN Med Locations

Vascular a1 Receptors

Answer 2

Prazosin
Terazosin
Labetalol

Question 3

Anti-HTN Med Locations

Renal Tubules

Answer 3

Thiazide Diuretics
Furosemide
K Sparing Diuretics

Question 4

Anti-HTN Med Locations

Brainstem

Answer 4

Clonidine

Methyldopa

Question 5

Anti-HTN Med Locations

Sympathetic Ganglia

Answer 5

Mecamylamine

Question 6

Anti-HTN Med Locations

Adrenergic Terminals

Answer 6

Guanethidine

Reserpine

Question 7

Anti-HTN Med Locations

Cardiac B1 Receptors

Answer 7

Propranolol
Metoprolol
B Blockers

Question 8

Anti-HTN Med Locations-

RAAS-B1 on JG Cells

Answer 8

Propranolol

Metoprolol

Question 9

Anti-HTN Med Locations-

RAAS- Renin

Answer 9

Aliskiren

Question 10

Anti-HTN Med Locations-

RAAS-ACE

Answer 10

Captopril

Enalapril

Question 11

Anti-HTN Med Locations-

RAAS- Ang 2 Receptors

Answer 11

Losartan

Valsartan

Question 12

Anti-HTN Med Locations-

RAAS- aldosterone receptors

Answer 12

Eplerenone

Spironolactone

Question 13

Ang 2 works @

AT-1 Recptors located @

Answer 13

Kidney 
   (>Na/H20/Cl)
Adrenal Gland
   (>aldosterone)
Arterioles
   ((vasoconstriction)
Pituitary Gland- post
   (> ADH)
> Sympathetic activity

Question 14

ACE-I

Uses

Answer 14

HTN
CHF (post MI)
Mitral Regurg
Delay Renal Disease progression 
  DM

Question 15

ACE-I

MOA

Answer 15

block conversion of Ang 1 to Ang 2 in vasc endothelium

interfere w/ zinc ion on ACE (peptidyl-dipeptidase)

Question 16

ACE-I

< in Ang 2
Effects

Answer 16

< arterial pressure (vasodilate)
< cardiac workload
< Blood Vol
< cardiac/vasc remodeling
> K+
fetal injury

Question 17

ACE-I

> Bradykinin
Effects

Answer 17

Vasodilation
Cough
Angioedema

(can’t break down bradykinin)

Question 18

ACE-I

SE

Answer 18

HoTN intraop
granulocytopenia
angioedema
persistant cough
Hyperkalemia

Question 19

ACE-I

Drug Intxs

Answer 19

NSAIDS
-antagonize effects
Anti-HTN Meds
-additive effect

Question 20

ACE-I

CIs

Answer 20

Pregnancy

Renal Artery Stenosis

Question 21

ARBs

MOA:

Answer 21

compeitively bind to inhibit action of ang 2 @ receptor

block vasoconstriction w/ no change in ACE

Question 22

ARBs

SE

Answer 22

same as ACE-I

w/out cough, angioedema
no > in bradykinin

Question 23

ARBs

CI

Answer 23

Pregnancy

Renal Artery Stenosis

Question 24

ARB meds

Answer 24

-sartans

Question 25

Hydralazine MOA

Answer 25

``` vasodilation via activation of guanylate cyclase + hyperpolarization = direct relaxant effect on vasc smooth muscle = < SVR ``` ARTERIES > veins

Question 26

Hydralazine Dose Peak DOA

Answer 26

2.5 - 10 mg iV 10-20 min peak last up to 6hrs

Question 27

Hydralazine Metab Onset E 1/2 T

Answer 27

Extensive hepatic 1st pass metab Onset: 15 min give slow E 1/2 T= 3 hrs

Question 28

Hydralazine SE

Answer 28

``` Angina w/ EKG changes Reflex >HR/ SV/ CO Tolerance Tachyphylaxis Na+/H2O retention Lupus like syndrome ```

Question 29

SNP Effect

Answer 29

Arterial + Venous relaxation | direct acting

Question 30

SNP MOA

Answer 30

SNP + oxyhemoglobin = Methemoglobin + NO + Cyanide ``` NO activate guanylate cylase = > cGMP = inhibit Ca entry > SR uptake of Ca+ = vasodilation ```