Endo Pharm Flashcards
Short Duration,
Fastest Acting Insulins?
Lispro
Aspart
Glulisine
Short Duration
Slower Acting Insulins?
Regular
Intermediate Duration,
slow acting?
NPH,
Detemir
Long Duration,
Slowest Acting Insulin?
Glargine
Which insulin can’t you mix with others?
Glargine
Lispro Kinetics
Onset: 10-15 m
Peak: 30m -1 hr
DOA: 3-5 hr
Regular Kinetics
Onset: 30-60 min
Peak: 1-5 hr
DOA: 5-8 hr
up to 10hrs
NPH Kinetics
Onset: 1-2 hr
Peak: 6-10 hr
DOA: 16-20 hr
Glargine Kinetics
Onset: 2-6 hr
Peak: NONE
DOA: 24 hr
Degludec
Onset: 2 hr
Peak: NONE
DOA: >40 hr
Hypoglycemia
TX
25-50 ml of 50% dextrose sln
fast acting oral sugar
Oral antidiabetic Meds
that may cause
Hypoglycemia?
Sulfonylureas
Meglitinides
GLP-1 Mimetics/ Gliptins
Vasopressin
USES
Diabetes Insipidus Esophageal Varices Hemorrhagic shock Septic Shock Cardiac arrest
Vasopressin
SE
↑ BP
CA Vasoconstriction
GI Hyper-peristalsis
Vasopressin
Receptor Action
V1= vasoconstriction
@ arterial SM
V2= >H2O permeability
= reabsorb H2O
@ collecting ducts
V3= ACTH release
Octreotide dose
for Carcinoid Crisis
50-100 mcg/hr
+
PRN Bolus
25-100 mcg
Glucagon
Dose
1-5 mg IV
OR
5 mcg/kg/min . [20mg/hr]