Final Meds Flashcards by Courtney Lentowich

Propylthiouracil PTU

Methimazole (Tapazole)

Anti Thyroid Meds
block organification by competing
w/ thyroglobulin for Iodide

SE:
low WBC, hepatotoxicity
Goiter

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Methimazole (Tapazole)

Longer 1/2 L, QD Dose

>potent =< SE

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Propylthiouracil

Also inhibit conversion in periphery
short 1/2 L
SE: Bleeding
TX: Thyroid Storm

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B Blocker

Endo Effect

Block T4 -> T3
+ symptom tx
Esmolol for thyroid storm

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Prednisone or Methylprednisone

Endo Effect

Block T4- T3 conversion

symptom Tx

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Iodide Salts

Lugol’s solution

Block T4 -> T3 Conversion
+ < vascularity of Thyroid gland

temporary prompt block of TH release from gland

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Levothyroxine

Synthesized T4

Long 1/2 L (7 day)

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T3 Liothyronine (Cytomel)

Use for myxedema coma

faster onset, shorter 1/2 L (1 day)

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Cortisol (Hydrocortisone)
Cortisol Succinate (solu-cortef)

corticosteroid
equal G & M effects
DOA 8-12 hr

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Cortisone

corticosteroid
less potent, last 8-36 hr
but equal G & M effects

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Prednisolone

corticosteroid
M & G effects
(4x G effects)
last 18 -26 hr

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Dexamethasone

Betamethasone

Corticosteroids
no M effect,
25x G Effect (most)
last 36-54 hr

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Somatostatin

GI Regulatory peptide

E 1/2 = 3min

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Glucagon

polypeptide hormone

vasodilates, > CO, biliary dilation

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Octreotide

Somatostatin analogue
Inhibit production + release of GI hormones
USE: 
carcinoid crisis
E 1/2 = 2.5 hr (longer)

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Arginine Vasopressin

Exogenous antidiuretic hormone
+ vasoconstricter
E1/2 = 10-20 min

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Desmopressin DDAVP

Synthetic analogue of AVP

E 1/2 = 2.4-4 hr

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NItroglycerine

Organic Nitrate
convert to NO = SM relaxation
E 1/2 L= 1.5 min

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Isosorbide

Organic Nitrate,
venodilator
long E 1/2 T

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Atenolol

B1 Antagonist

water soluble

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Metoprolol

B1 Selective Antagonist
lipid soluble
DOA 3-4 hr

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Verapamil

Phenylalkylamine CCB

< HR/Contractility

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Nifedipine
Amlodipine
Nicardipine
Felodipine

Dihydropyridine CCB

Vasc relaxation,

Diltiazem

Modified Benzothiazepines

Vasc + Cardiac selectivity

Ranolazine

Inhibit Late Na Current = < Ca >CO, no change in HR/BP >QT CYP 3A4

Aspirin

Acetylsalicylic Acid Irreversible TXA2 inhibition =plt inhibition

Spironolactone

Aldosterone Receptor Blocker | < remodeling

Ramipril

Angiotensin Converting Enzyme Inhibitor | < remodeling

Valsartan

Angiotensin 2 Receptor Blockers AT2 receptors on arterial vasculature < remodeling

Sacubitril/valsartan

Angiotensin- Neprilysin Inhibitors | ARNIs

Digoxin

Cardiac Glycoside Inotropic Agent Inhibit Na/K/ATPase pump

Furosemide Bumetanide Torsemide

Loop Diuretics

Dobutamine

Sympathomimetic: Inotropic Agent B1 stimulation: > Contractility B2: arterial vasodilation

Amrinone | Milrinone

Selective PDE 3, Phosphodiesterase Inhibitors | Inodilators

Glyipizide, Glyburide Glimepiride Tolbutamide Chlorpropamide

Sulfonylureas Hypoglycemia hold 24-48 hr PREOP

Repaglinide | Nateglinide

Meglitinides Hypoglycemia

Sitagliptin

GLP1 Mimetics/ Gliptins Hypoglycemia inhibit DPP4 enzyme = >incretin hormone (GLP1)

Extenatide (Byetta)

Synthetic GLP1 Analog ``` Hypoglycemia Mimics GLP1 (incretin hormone) ```

Pramlintide

Synthetic analog of amylin Hypoglycemia Metab in kidney

Metformin

Biguanides < hepatic glucose production

Pioglitazone | Rosiglitazone

Thiazolidinediones improve insulin sensitivity Hepatotoxcity Cardiac Probs

Acarbose (precose | Miglitol (glyset)

Alpha-Glucosidase Inhibitors MOA: < enzymes @ brush boarder

Budesonide Beclomesthasone Triamcinolone Fluticasone

Inhaled Corticosteroids

Zileuton Zafirlukast Montelukast

Leukotrienes Inhibitors < Leukotriene effects

Omalizumab

Anti-IgE Antibodies bind to IgE in blood

Albuterol | Levalbuterol

Short Acting B Agonsit

Salmeterol | Terbutaline

Long Acting B Agonsit

Theophylline | Aminophylline

Methylxanthines MOA unclear

Atropine Ipratropium bromie Tiotropium

Anti-Cholinergics Competitive antagonist @ Muscarinic receptors (M3)

Enoxaparin Daltaparin Fondaparinux Tinzaparin

LMWH

Xa Inhibitors

Rivaroxaban (Xarelto) | Apixaban (eliquis)

Lepirudin (Refludan) Bilvarudin (angiomax) Argatroban Dabigatron (Pradaxa)

Direct Thrombin Inhibitors

Ticlopidine (ticlid) Clopidogrel (Plavix) Aspirin/dipyridamole (aggrenox)

P2Y12ADP antagonists Anti-plt drug

Abciximab (reopro) Tirofiban (Aggrestat) Eptifibatide (Integrilin)

G2b/3a Antagonist Anti-Plt Drug

Streptokinase Urokinase tPA (alteplase)

Thrombolytic Drugs

``` Lysine analogs (TXA) Aprotinin ```

Anti-fibrinolytic Agents Procoagulants

Recombinant Proteins Procoagulants

Activated Factor 7a Factor 13 Prothrombin concentrates