HTN drugs Flashcards
1
Q
What are the targets of Angiotensin 2?
A
Vasculature Aldosterone (sodium reuptake) Pituitary gland (ADH secretion, water reabsorption)
2
Q
Recap RAS
A
Decrease in renal perfusion stimulates kidney renin, which converts angiotensinogen from the liver to angiotensin 1. ACE, produced from the lungs, converts Ang 1 to Ang 2.
3
Q
Differentiate between diltiazem vs amlodipine
A
Amlodipine - works more on vessels
Diltiazem - directly targets the heart
4
Q
Differentiate between diltiazem vs amlodipine
A
Amlodipine - works more on vessels, therefore less interference with heart conditions
Diltiazem - directly targets the heart
5
Q
Problem with amlodipine?
A
Rebound tachycardia induced by baroreceptors
6
Q
Where do thiazide diuretics work?
A
Sodium chloride channel in the distal tubule
7
Q
SE of ACEi/ARb
A
Renal impairment
Hyperkalemia
Cough
Rash
8
Q
SE of CCB
A
Ankle swelling Headaches Vasodilation Constipation Palpitations Abdo pain
9
Q
SE of thiazides
A
Hypotension and renal impairment Hypokalemia Gout Diabetes (interfere with insulin secretion) Impotence
