HSS (11.13 - febrile seizure article)

Question 1

what was the point of the study

Answer 1

they want to know whether
MMRV (measles-mumps-rubella-varicella) vaccine
may INCREASE risk of febrile seizures

more so than the past vaccine: MMR and varicella (separate)

Question 2

what did they measure

Answer 2

compare risk of seizures after first dose of MMRV

with the

risk of s after MMR and varicella (MMR + V) (separate) vaccine

Question 3

what was the study design

Answer 3

retrospective
population based
cohort

Question 4

what was the study pop

Answer 4

children 12 to 24 month old

Question 5

result

Answer 5

• risk of seizure after vacc was TWICE as high with MMRV

- however, absolute level of risk was small (3 per 10K doses)

Question 6

how did they gather their data

Answer 6

use data in database (universal healthcare system in Canada)